The Barocycler NEP3229 is a lightweight, portable, and affordable instrument designed to fit on a laboratory bench top, inside a biological safety cabinet, or on the shelf of a cold room. The NEP3229 is capable of processing up to three samples simultaneously. The NEP3229 has an external chiller hook-up, automatic fill and dispense valves, and a microprocessor with an easy-to-use keypad. The Barocycler NEP3229 fills an important and growing need in the genomics, transcriptomics and proteomics sample preparation market for a small affordable instrument that provides safety, quality, versatility and reproducibility.