Gary B. Smejkal1,3, George O. Poinar Jr.2, Feixia Chu3 and Pier Giorgio Righetti4 1 Harvard Catalyst, Harvard Clinical and Translational Science Center, Laboratory for Innovative Translational Technologies, Boston, MA, USA. 2 Oregon State University, Department of Zoology, Corvallis, OR, USA. 3 University of New Hampshire, Hubbard Center for Genome Studies, Durham, NH, USA. 4 Politecnico di Milano, Department of Chemistry, Materials, and Chemical Engineering, Milan, Italy.

Nolwennig Rivalaina,c, Jean Roquainb,c, G�rard Demazeaua,c ICMCB-CNRS � Universit� de Bordeaux � 87, avenue du Dr. Albert Schweitzer, 33608 PESSAC Cedex, France Universit� Victor S�galen Bordeaux 2 � Universit� de Bordeaux � 146, rue L�o Saignat, 33076 Bordeaux Cedex, France Plateforme Technologique d'Innovation Biom�dicale, Avenue du Haut L�v�que, 33600 PESSAC, France

Shiying Shao a,b, Tiannan Guo b, Ruedi Aebersold b,c, a Division of Endocrinology, Tongji Hospital, Huazhong University of Science & Technology, Wuhan 430030, PR China b Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Wolfgang-Pauli-Str. 16, 8093, Switzerland c Faculty of Science, University of Zurich, 8057 Zurich, Switzerland Biochimica et Biophysica Acta 1854 (2015) 519-527

Natalia Pripuzova, Melkamu Getie-Kebtie, Christopher Grunseich, Colin Sweeney, Harry Malech and Michail Alterman Tumor Vaccine and Biotechnology Branch, Division of Cellular and Gene Therapies, Office of Cellular, Tissue and Gene Therapies Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, MD; Neurogenetics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD; Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.

L.V. Schneider¹, V. Likhte¹, W. Wright¹, F. Chu¹, E. Cambron¹, A. Baldwin1, J. Krakow¹, A. Lazarev², G. Smejkal³

¹Target Discovery, Inc. ²Pressure BioSciences, Inc., ³Harvard LITT