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Metabolism and MitochondriaMetabolism and MitochondriaIsolation of functional mitochondria from rat kidney and skeletal muscle without manual homogenization Vera S. …metabolism-and-mitochondria
GlycomicsGlycomicsA multiplexed microflow LC–MS/MS-PRM assay for serologic quantification of IgG N- and HPX O- glycoforms …glycomics
ForensicsForensicsIsolation of Mitochondrial DNA from Single, Short Hairs without Roots Using Pressure Cycling Technology. Harper …forensics
Food SafetyFood SafetyFate and Biofilm Formation of Wild-Type and Pressure-Stressed Pathogens of Public Health Concern in Surface …food-safety
Epitope MappingEpitope MappingPotency under pressure: the impact of hydrostatic pressure on antigenic properties of influenza virus hemagglutinin …epitope-mapping
EnvironmentalEnvironmentalLignin induced iron reduction by novel sp., Tolumonas lignolytic BRL6-1 Gina Chaput, Andrew F. Billings, Lani DeDiego, …environmental
ChemistryChemistrySelective reduction of ketones using water as a hydrogen source under high hydrostatic pressure. Tomin …chemistry
BiophysicsBiophysicsThe consequences of cavity creation on the folding landscape of a repeat protein depend upon …biophysics
Strategies to enable large-scale proteomics for reproducible researchProteomicsRebecca C. Poulos,#1 Peter G. Hains,#1 Rohan Shah,#1 Natasha Lucas,1 Dylan Xavier,1 Srikanth S. Manda,1 Asim Anees,1 Jennifer M. S. Koh,1 Sadia Mahboob,1 Max …proteomics
Putting Pressure on Quality Research, Drug Development, and Cannabis (CBD) ProductsPharma’s Almanac Q1 2020 Volume 6 Number 1
Solutions for Maximizing the Bioavailability of CBD and BeyondMark Golombek Cannabis Brightline  
The Undeniable Advantages of Water-Soluble CBDKen Micciche Director UST Program, Advanced Technology for Cosmetic, Food & Beverage, Nutraceutical, Pharmaceutical Nanoemulsion Research …
Molecular Epitope Determination of Aptamer Complexes of the Multiâ€_x0090_domain Protein Câ€_x0090_Met by Proteolytic Affinityâ€_x0090_ Mass SpectrometryProteomicsMichael Przybylski; Loredana Lupu; Pascal Wiegand; Nico Hüttmann; Stephan Rawer; Wolfgang Kleinekofort; Irina Shugorevai; Anna …proteomics
Epitope Identification and Affinity Determination of an Inhibiting Human Antibody to Interleukin IL8 (CXCL8) by SPR- Biosensor–Mass Spectrometry CombinationPascal Wiegand; Loredana Lupu; Nico Hüttmann; Julia Wack; Stephan Rawer; Michael Przybylski; Katja Schmitz Steinbeis …
ACE over expression in myeloid cells increases oxidative metabolism and cellular ATPPeer ReviewedDuo-Yao Cao1, Weston R. Spivia2, Luciana C. Veiras1, Zakir Khan1,3, Zhenzi Peng1, Anthony E. Jones4, …peer-reviewed
Pressure Cycling Technologyâ€_x0090_Assisted Mass Spectrometric Quantification of Gingival Tissue Reveals Proteome Dynamics During the Initiation and Progression of Inflammatory Periodontal DiseaseProteomicsXiaofei Li; Tetsuhiro Kajikawa; Abe Toshiharu; Nathalie Selevsek; Jonas Grossmann; George Hajishengallis; Nagihan Bostanciproteomics
Advances in Prevention of Foodborne Pathogens of Public Health Concern during ManufacturingPeer ReviewedAliyar Cyrus Fouladkhah (Editor), Bledar Bisha (Editor)peer-reviewed
Development of an Efficient LC-MS Peptide Mapping Method Using Accelerated Sample Preparation for Monoclonal AntibodiesPing Jianga Fumin Lib Jie Dinga aPPD, 8551 Research Way, Middleton, WI 53562 bPPD, 3230 Deming Way, Middleton, WI 53562
Accelerated Protein Biomarker Discovery from FFPE tissue samples using Single-shot, Short Gradient Microflow SWATH MSPeer ReviewedRui Sun, Christie Hunter, Chen Chen, Weigang Ge, Nick Morrice, Shuang Liang, Chunhui Yuan, Qiushi Zhang, Xue Cai, Xiaoyan Yu, Lirong Chen, Shaozheng Dai, Zhongzhi Luan,  Ruedi Aebersold, Yi Zhu, Tiannan Guopeer-reviewed
Quantitative proteome landscape of the NCI-60 cancer cell linesPeer ReviewedTiannan Guo, Augustin Luna, Vinodh N. Rajapakse, Ching Chiek Koh, Zhicheng Wu, Wei Liu, Yaoting …peer-reviewed
NANOEMULSION PROCESS SCHEMATICPoster 3 of 3
Revolutionary System for High Quality, Stable, Water Soluble CBD NanoemulsionsPoster 2 of 3
Oil & Water DO Mix – with UST ProcessingPoster 1 of 3
The emergence of proteomic big data research for precision medicineTiannan Guo Westlake University
Proteogenomic Characterization of Human CancerYang Du, Ph.D. Center for Cancer Bioinformatics Peking University Cancer Hospital & Institute
ThyroProt: a robust protein classification system for diagnosing thyroid nodules using deep learning of proteome expressionYaoting Sun Guomics Laboratory for Proteomic Big Data http://www.guomics.com/
Proteomic Dynamics of Colorectal Cancer Evolution Identifies Microenvironment Modulator PLOD2 as a Potential Novel Drug TargetKailun Xu1,2 , Yingkuan Shao1,2, Xi Zheng1,2, Biting Zhou1, Yi Zhu2, Shu Zheng*1, Tiannan Guo*2 …
Extensive Intratumor Proteogenomic Heterogeneity Revealed by Multiregion Sampling in a High-Grade Serous Ovarian Tumor SpecimenPeer ReviewedAllison L. Hunt, Nicholas W. Bateman, Brian L. Hood, Kelly A. Conrads, Ming Zhou, Tracy …peer-reviewed
High-pressure EPR spectroscopy studies of the E. coli lipopolysaccharide transport proteins LptA and LptPeer ReviewedSchultz KM1, Klug CS1  Appl Magn Reson | 2017 Dec;48(11-12):1341-1353 | doi: 10.1007/s00723-017-0948-zpeer-reviewed
Real time insights into pressure mediated protein refolding: Reversible inactivation of alkaline phosphatase at high pressure.Gary Smejkal, Edmund Ting, Vera Gross, Nicole Cutri, Alexander Lazarev Poster | Pressure BioSciences
High Pressure Optical Spectroscopy ( HiPOS ) and Real Time Analysis of Enzymes Kinetics at Elevated Hydrostatic PressureGary Smejkal, Edmund Ting, Vera Gross, Nicole Cutri, Alexander Lazarev Poster | Pressure BioSciences
A Barocycler-based Concurrent Multi-Omics Method to Assess Molecular Changes Associated with Atherosclerosis using Small Amounts of Arterial Tissue from a Single MousePeer ReviewedJihan Talib,  Peter G Hains,  Sergey Tumanov,  Mark P. Hodson,  Phillip J. J Robinson, and  …peer-reviewed
Relationships between airborne pollutants, serum albumin adducts and short-term health outcomes in an experimental crossover studyPeer ReviewedGeorge W.Prestona, Sonia Dagninob, Erica Ponzibc, Osman Sozeria, Karin van Veldhovenb, Benjamin Barratta, Sa Liud1, Hasmik Grigoryand, Sixin S.Lud, Stephen M.Rappaportd, Kian Fan Chungef, Paul Cullinanef, Rudy Sinharayg, Frank J.Kellya, Marc Chadeau-Hyamb, Paolo Vineisb, and David H.Phillipsa a MRC-PHE Centre for Environment & …peer-reviewed
Mapping the N-Terminome in Tissue Biopsies by PCT-TAILSProteomicsLouise Bundgaard, Simonas Savickas, and Ulrich auf dem Keller Department of Biotechnology and BiomedicineTechnical University of Denmark, Kongens Lyngby, Denmarkproteomics
Addressing the challenges of high-throughput cancer tissue proteomics for clinical application: ProCan®Peer ReviewedBrett Tully, Rosemary L. Balleine, Peter G. Hains, Qing Zhong, Roger R. Reddel, Phillip J. …peer-reviewed
Identification of Heat-Induced Proteomes in Tomato Microspores Using LCMProteomics AnalysisLi H1; Zhu Y1; Rangu M1; Wu X1; Bhatti S1; Zhou S1; Yang Y2; Fish T2; and Thannhauser TW2 1Department of Agricultural …
The pressure and temperature perturbation approach reveals a whole variety of conformational substates of amyloidogenic hIAPP monitored by 2D NMR spectroscopyPeer ReviewedMarkus Beck Erlacha; Hans Robert Kalbitzera; Roland Winterb; Werner Kremera Biophysical Chemistry | Volume 254 | …peer-reviewed
High-throughput proteomic analysis of FFPE tissue samples facilitates tumor stratificationYi Zhu 1,2,3*,Tobias Weiss 4 *, Qiushi Zhang 1,2, Rui Sun 1,2, Bo Wang 5 …
Integrated transcriptomic and proteomic analysis of human eccrine sweat glands identifies missing and novel proteinsProteomicsChan Hyun Na1,2,3,4, Ç‚ , Neeraj Sharma1, Ç‚ , Anil K. Madugundu1,7,8, Ruiqiang Chen1,2, Melis …proteomics
High-throughput proteomic analysis of FFPE tissue samples facilitates tumor stratificationPCT-HD (PCT-SWATH)Yi Zhu 1,2,3*,Tobias Weiss 4 *, Qiushi Zhang 1,2, Rui Sun 1,2, Bo Wang 5 …pct-hd-pct-swath
An integrated Pipeline from SWATH acquisition to MRMHR workflow facilitates Identification and Verification of Prostate Diagnostic MarkersRui Sun 1*, Christie Hunter 2*#, Chen Chen 3, Huanhuan Gao 1, Xue Cai 1, …
Oncoproteomics: Current status and future opportunitiesPeer ReviewedYujia Hea1Abidali Mohamedalib1Canhua Huanga Mark S.Bakerc Edouard C.Niceacd aWest China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, …peer-reviewed
Microflow DIA Using 15 min Gradients Analyzes 40 Tumor Proteomes per Day and Effectively Detects Promising Protein BiomarkersRui Sun 1*, Christie Hunter 2*#, Chen Chen 3, Huanhuan Gao 1, Xue Cai 1, …
DPHL: A Computational MS/MS Data Resource Enabling Robust Protein Biomarker Discovery using Data-Independent Acquisition and Parallel Reaction MonitoringTiansheng Zhu1,2,30 #, Yi Zhu 1,2 #, Yue Xuan3 #, Huanhuan Gao1,2, Xue Cai1,2, Sander …
Brain Citrullination Patterns and T Cell Reactivity of Cerebrospinal Fluid-Derived CD4+ T Cells in Multiple SclerosisProteomicsWolfgang Faigle,1Carolina Cruciani,1Witold Wolski,2Bernd Roschitzki,2Marco Puthenparampil,1Paula Tomas-Ojer,1Carla Sellés-Moreno,1Thomas Zeis,3Ivan Jelcic,1Nicole Schaeren-Wiemers,3Mireia Sospedra,1,†and Roland Martin1,*†proteomics
Streamlined PCT-HD: Alternative Method for Improved Results Using Higher Pressure Trypsin Digestion or N-PropanolThe PCT-HD workflow (also known as PCT-SWATHTm or PCT-ABLE) is a combination of two of …
Streamlined PCT-HD Workflow: Simplified Protocol with Fewer Steps and Less Hands-on Time IIThe PCT-HD workflow (also known as PCT-SWATHTm or PCT-ABLE) is a combination of two of …
Interactions of Carvacrol, Caprylic Acid, Habituation, and Mild Heat for Pressure-Based Inactivation of O157 and Non-O157 Serogroups of Shiga Toxin-Producing Escherichia coli in Acidic EnvironmentFood ScienceMd Niamul Kabir1, Sadiye Aras1, Abimbola Allison1, Jayashan Adhikari1, Shahid Chowdhury1 and Aliyar Fouladkhah1,2  1Public …food-science
Modified PCT-HD Workflow: Simplified Protocol with Fewer Steps and Less Hands-on TimeThe PCT-HD workflow (also known as PCT-SWATHTm or PCT-ABLE) is a combination of two of …
Pressure-enhanced Disaggregation and Solubilization of Aggregated β-casein ProteinProteomics Application NotesIntroduction Disaggregation and solubilization of protein aggregates in mild reagents is challenging. Most disaggregation protocols …proteomics-application-notes
Video: How a World Leader in Pressure Technology Made CBD Oil Truly Water SolubleVideo: How a World Leader in Pressure Technology Made CBD Oil Truly Water Soluble
Video: A Revolution in Mixing Oil and WaterVideo: A Revolution in Mixing Oil and Water
Video: CBD-Infused Beverages Achieve Quality and Clarity Breakthrough Utilizing Pressure BioSciences™ Ultra Shear Technology PlatformVideo: CBD-Infused Beverages
Identification of Salmonella taxon-specific peptide markers to the serovar level by mass spectrometryPeer ReviewedShu-Hua Chen, Christine H. Parker, Timothy R Croley, and Melinda A. McFarlandpeer-reviewed
III. Effect of High Pressure and Temperature on Papainase Digestion RateINTRODUCTION High hydrostatic pressure (HPP) has been used for decades in the food industry for …
Epitope Ligand Binding Sites of Blood Group Oligosaccharides in Lectins Revealed by Pressure-Assisted Proteolytic Excision Affinity Mass SpectrometryPeer ReviewedBaschung Y1,2, Lupu L1, Moise A3, Glocker M2, Rawer S4, Lazarev A5, Przybylski M6,7   1 Steinbeis Centre for Biopolymer Analysis …peer-reviewed
Generation of a zebrafish SWATH-MS spectral library to quantify 10,000 proteinsPeer ReviewedPeter Blattmann,a,1,* Vivienne Stutz,1,* Giulia Lizzo,2 Joy Richard,2 Philipp Gut,2 and Ruedi Aebersoldb,1,3 1Department of Biology, Institute of Molecular Systems Biology, …peer-reviewed
Isolation and characterization of Lactobacillus-derived membrane vesiclesPeer Reviewed1Scott N. Dean, 2Dagmar H. Leary, 3Claretta J. Sullivan, 4Eunkeu Oh and 2Scott A. Walper  1National …peer-reviewed
Proteome and transcriptome profiling of equine myofibrillar myopathy identifies diminished peroxiredoxin 6 and altered cysteine metabolic pathwaysPeer ReviewedStephanie J. Valberg,1,2Sudeep Perumbakkam,3Erica C. McKenzie,4 and Carrie J. Finno5peer-reviewed
Co-option and Detoxification of a Phage Lysin for Housekeeping FunctionPeer ReviewedAmelia M. Randich1, David T. Kysela1, Cécile Morlot2, Yves V. Brun1 1Indiana University, Bloomington, IN USA, Bloomington, …peer-reviewed
Application of high hydrostatic pressure to dissociate aggregates and refold proteins.Peer ReviewedSeefeldt MB1, Rosendahl MS, Cleland JL, Hesterberg LK. BaroFold Inc., Boulder, CO 80301, USA.peer-reviewed
Specific volume and adiabatic compressibility measurements of native and aggregated recombinant human interleukin-1 receptor antagonist: density differences enable pressure-modulated refolding.Peer ReviewedSeefeldt MB1, Crouch C, Kendrick B, Randolph TW. Department of Chemical and Biological Engineering, University of Colorado, Boulder, …peer-reviewed
High-pressure studies of aggregation of recombinant human interleukin-1 receptor antagonist: thermodynamics, kinetics, and application to accelerated formulation studies.Peer ReviewedSeefeldt MB1, Kim YS, Tolley KP, Seely J, Carpenter JF, Randolph TW Department of Chemical and Biological Engineering, Center for …peer-reviewed
High-pressure refolding of bikunin: efficacy and thermodynamics.Peer ReviewedSeefeldt MB1, Ouyang J, Froland WA, Carpenter JF, Randolph TW. Department of Chemical and Biological Engineering, Center for Pharmaceutical …peer-reviewed
High hydrostatic pressure as a tool to study protein aggregation and amyloidosis.Peer ReviewedRandolph TW, Seefeldt M, Carpenter JF. Department of Chemical Engineering, University of Colorado, Boulder, CO …peer-reviewed
Confronting high-throughput protein refolding using high pressure and solution screensPeer ReviewedM. Walid Qoronfleha,*, Lyndal K. Hesterbergb, Matthew B. Seefeldtb aUniversity of Michigan and Core Technology …peer-reviewed
Characterization of longitudinal canal tissue in the acorn barnacle Amphibalanus amphitriteProteomicsChenyue Wang , Janna N. Schultzhaus , Chris R. Taitt, Dagmar H. Leary, Lisa C. Shriver-Lake, Daniel …proteomics
Slides: Inactivation of Salmonella serovars and rifampicin resistant Escherichia coli O157:H7 in apple cider using high pressure pasteurizatioFood ScienceJ. ADHIKARI and ALIYAR FOULADKHAH PUBLIC HEALTH MICROBIOLOGY LABORATORY, TENNESEE STATE UNIVERSITYfood-science
Slides: Prevention of Planktonic and Sessile Pathogens of Public Health Concern Using an Emerging TechnologyFood ScienceAbimbola Allison  and Dr. Aliyar Fouladkhah Public Health Microbiology Laboratory, Tennessee State Universityfood-science
Slides: Pressure-based Inactivation of Rifampicin-resistant Cronobacter sakazakiiin Infant FormulaFood ScienceMONICA HENRY and ALIYAR FOULADKHAH PUBLIC HEALTH MICROBIOLOGY LABORATORY, TENNESSEESTATE UNIVERSITYfood-science
Disaggregation of Proinsulin Inclusion Bodies by High PressureProteomics Application NotesIntroduction Protein expression in E. coli is an efficient and commonly used method to generate …proteomics-application-notes
Accelerated Barocycler Lysis and Extraction (ABLE) sample preparation for clinical proteomics by mass spectrometry.PCT-HD (PCT-SWATH)Lucas N, Robinson AB, Marcker Espersen M, Mahboob S, Xavier D, Xue J, Balleine RL, deFazio A, Hains PG, Robinson PJ pct-hd-pct-swath
Real time high pressure optical spectroscopy in biochemical studies: Pressure perturbation of pH and enzymatic activityGary Smejkal, Alana Murphy, Vera Gross, Nicole Cutri, and Alexander Lazarev Pressure BioSciences, Inc., South …
Identification of Protein Abundance Changes in Hepatocellular Carcinoma Tissues using PCT-SWATH.Peer ReviewedZhu Y1,2, Zhu J3, Lu C3, Zhang Q1, Xie W3, Sun P4, Dong X5, Yue L1, Sun Y1, Yi X1, Zhu T1, Ruan G1, Aebersold R2,6, Huang S3, Guo …peer-reviewed
The LINK-A lncRNA interacts with PtdIns(3,4,5)P3 to hyperactivate AKT and confer resistance to AKT inhibitorsPeer ReviewedAifu Lin1,14,15, Qingsong Hu1,15, Chunlai Li1,15, Zhen Xing1, Guolin Ma2, Cheng Wang3, Jun Li4,5, Yin …peer-reviewed
Sensitivity of Salmonella Serovars and Natural Microflora to High-Pressure Pasteurization: Open Access Data for Risk Assessment and PractitionersFood ScienceAbimbola Allison and Aliyar Fouladkhah Public Health Microbiology Laboratory, Tennessee State University, Nashville, TNfood-science
Synergism of Mild Heat and High-Pressure Pasteurization Against Listeria monocytogenes and Natural Microflora in Phosphate-Buffered Saline and Raw MilkFood ScienceAbimbola Allison 1 , Shahid Chowdhury 1,2 and Aliyar Fouladkhah 1,2,* 1.  Public Health Microbiology …food-science
Functional metagenomics identifies an exosialidase with an inverting catalytic mechanism that defines a new glycoside hydrolase family (GH156)Peer ReviewedLéa Chuzel1,2, Mehul B. Ganatra1, Erdmann Rapp2,3, Bernard Henrissat4,5,6 and Christopher H. Taron1*   1New England …peer-reviewed
Proteomic analysis reveals an extract of the plant Lippia origanoides suppresses mitochondrial metabolism in triple-negative breast cancer cells.Peer ReviewedVishak Raman, Uma K. Aryal, Victoria Hedrick, Rodrigo Mohallem Ferreira, Jorge Luis Fuentes Lorenzo, Elena E. Stashenko, Morris Levy, Maria M. Levy, …peer-reviewed
Quantitative Liquid Chromatography-Mass Spectrometry-Multiple Reaction Monitoring (LC-MS-MRM) Analysis of Site-specific Glycoforms of Haptoglobin in Liver DiseasePeer ReviewedMiloslav Sanda, Petr Pompach, Zuzana Brnakova, Jing Wu, Kepher Makambi and Radoslav Goldman Departments of Oncology and Biochemistry and Molecular and Cellular …peer-reviewed
Quantitative analysis of the murine lipid droplet-associated proteome during diet-induced hepatic steatosisPeer ReviewedSalmaan A. Khan, Edith E. Wollaston-Hayden, Todd W. Markowski, LeeAnn Higgins and Douglas G. Mashek University of Minnesota, United …peer-reviewed
An Ixodes scapularis cell line with a predominantly neuron-like phenotypePeer ReviewedJonathan D. Oliver, Adela S. Oliva Chávez, Roderick F. Felsheim, Timothy J. Kurtti, Ulrike G. Munderloh Department of Entomology, University of Minnesota, St. Paul, USA UMR …peer-reviewed
A repository of assays to quantify 10,000 human proteins by SWATH-MSPeer ReviewedGeorge Rosenberger, Ching Chiek Koh, Tiannan Guo, Hannes L. Röst, Petri Kouvonen, Ben C. Collins, Moritz Heusel, Yansheng Liu, Etienne Caron, Anton Vichalkovski, Marco Faini, Olga …peer-reviewed
N-Glycosylation Characterization by Liquid Chromatography with Mass SpectrometryPeer ReviewedSong Klapoetke KBI Biopharma, Durham, USApeer-reviewed
Pressure response of amide one-bond J-couplings in model peptides and proteinsPeer ReviewedJoerg Koehler, Markus Beck Erlach, Edson Crusca Jr., Werner Kremer, Claudia E. Munte, Alexander Meier, Hans Robert Kalbitzer Journal of Biomolecular NMR | volume 60 | pages45–50(2014)peer-reviewed
The consequences of cavity creation on the folding landscape of a repeat protein depend upon contextPeer ReviewedKelly A. Jenkins, Martin J. Fossat, Siwen Zhang, Durgesh K. Rai, Sean Klein, Richard Gillilan, Zackary White, Grayson Gerlich, Scott A. McCallum, Roland Winter, Sol …peer-reviewed
Green coffee bean extract and 5-O-caffeoylquinic acid regulate fat metabolism in Caenorhabditis elegans (2)Peer ReviewedRenalison Farias-Pereiraa; Jordan Oshirob; Kee-Hong Kimbc; Yeonhwa Parka a Department of Food Science, University of …peer-reviewed
Crystal Structures of the Catalytic Domain of Arabidopsis thaliana Starch Synthase IV, of Granule Bound Starch Synthase From CLg1 and of Granule Bound Starch Synthase I of Cyanophora paradoxa Illustrate Substrate Recognition in Starch SynthasesMorten M. Nielsen1, Christian Ruzanski1†, Katarzyna Krucewicz1, Alexander Striebeck1, Ugo Cenci2, Steven G. Ball2, Monica …
Fast and Efficient non-reduced Lys-C digest using pressure cycling technology for antibody disulfide mapping by LC–MSPeer ReviewedYing Cheng*; Yonghong Chen; Christopher Yu Protein Analytical Chemistry, Genentech Inc., 1 DNA Way, South San …peer-reviewed
Pressureâ€_x0090_ and Heatâ€_x0090_Induced Protein Unfolding in Bacterial Cells: Crowding vs. StickingPeer ReviewedTimothy Chen; Kapil Dave; Martin Gruebelepeer-reviewed
Integrated Stress Response and Decreased ECM in Cultured Stromal Cells from Keratoconus CorneasPeer ReviewedJames W. Foster; Vishal Shinde; Uri S. Soiberman; Gajanan Sathe; Sheng Liu; Julius Wan; Jiang Qian; Yassine Dauoud; Akhilesh Pandey; Albert S. Jun; Shukti Chakravartipeer-reviewed
Surface Modification of Polymer Nanoparticles with Native Albumin for Enhancing Drug Delivery to Solid TumorsPeer ReviewedHyesun Hyuna; Joonyoung Parka; Kiela Willisb; Ji Eun Parkc; L. Tiffany Lyled; Wooin Leec; Yoon Yeoa,e aDepartment of Industrial and Physical Pharmacy, Purdue University, 575 Stadium Mall Drive, …peer-reviewed
Interview with Professor Michael PrzybylskiInterview with Professor Michael Przybylski ACCELLERATING BIOPHARMACEUTICAL CHARACTERIZATION
Poster: Towards a High-Pressure Structural Biology Instrumentation Suite at CHESSDurgesh K. Rai1; Edmund Ting2; Alexander V. Lazarev2; Zhongwu Wang1; Richard E. Gillilan1; Roland Winter3; …
Presentation: Towards a High-Pressure Structural Biology Instrumentation Suite at CHESSDurgesh K. Rai*; Edmund Ting; Alexander V. Lazarev; Zhongwu Wang; Richard E. Gillilan; Roland Winter; …
Proteomics Reveals Rictor as a Non-Canonical TGFB Signaling Target During Aneurysm Progression in Marfan MicePeer ReviewedSarah J Parker Ph.D.*; Aleksandr Stotland; Elena MacFarlane; Nicole Wilson; Amanda Orosco; Vidya Venkatraman; Kyle Madrid; Roberta …peer-reviewed
Effects of Conjugated Linoleic Acid (CLA) on Fat Accumulation, Activity, and Proteomics Analysis in Caenorhabditis elegansPeer ReviewedPeiyi Shen; Jonathan C. Kershaw; Yiren Yue; Ou Wang; Kee-Hong Kim; Julian McClements; Yeonhwa Parkpeer-reviewed
Structure Identification and Affinity Characterization of Soybean Agglutinin- Carbohydrate Interaction Epitopes Using Proteolytic Affinity- Mass Spectrometry (PROTEX-MS)ProteomicsYannick Baschung1,2; Loredana Lupu1,2; Michael Glocker2; Michael Przybylski1 1Steinbeis Analysis & Biomedical Mass Spectrometry, Rüsselsheim, …proteomics
Identification and Affinity Determination of Antibody Epitopes against the Chemokine CXCL8 by High-Pressure Proteolytic Extraction Mass Spectrometry and Biosensor AnalysisProteomicsPascal Wiegand1,2; Nico Hüttmann1,2; Julia Wack2; Loredana Lupu1,3; Alexander Lazarev4; Katja Schmitz2 and Michael Przybylski1 …proteomics
High-Pressure Enzymology: The Synergistic Effect of High Pressure and Temperature on Trypsin, Chymotrypsin, and Lysyl Endopeptidase Digestion Rates: Effects of High Pressure and Temperature on Protease ActivityGary Smejkal; Alana Murphy; Vera Gross; Nicole Cutri; Alexander Lazarev Pressure BioSciences, Inc., South Easton …
Recent Validation Studies using Elevated Hydrostatic Pressure and Synergism with Heat and Natural Antimicrobials  Aliyar Fouladkhah, PhD, MPH, CFS, CPH Assistant Professor, Tennessee State University Founder/Director, Public Health …
High pressure UV-Vis absorbance spectroscopy and enzyme kinetics: Effects of high pressure and temperature on protease activityProteomicsGary Smejkal; Alana Murphy; Vera Gross; Nicole Cutri; Alexander Lazarev Pressure BioSciences, Inc., South Easton …proteomics
High Pressure Food Processing (HPP)Food ScienceEdmund Ting, Sc.D., Senior VP Engineering Pressure BioSciences Inc.food-science
Cys34 Adductomes Differ between Patients with Chronic Lung or Heart Disease and Healthy Controls in Central LondonPeer ReviewedSa Liu;† Hasmik Grigoryan;† William M. B. Edmands;† Sonia Dagnino;‡ Rudy Sinharay;§,∥ Paul Cullinan;§,∥ Peter Collins;§,∥ …peer-reviewed
Protein In-Gel Digestion Using Pressure Cycling Technology for Identification by LCMSMSTatiana N. Boronina1; Lauren R. DeVine1; and Robert N. Cole1 1Mass Spectrometry and Proteomics Facility …
Selection and Detection of Taxon-Specific Peptide Markers for Identification of Salmonella to the Serovar Level by Mass SpectrometryShu-Hua Chen; Christine H. Parker; Timothy R. Croley; Melinda A. McFarland Spectroscopy and Mass Spectrometry …
A Comparative In Vivo Study of Albuminâ€_x0090_Coated Paclitaxel Nanocrystals and AbraxanePeer ReviewedJoonyoung Park; Ji Eun Park; Victoria E. Hedrick; Karl V. Wood; Connie Bonham; Wooin Lee; Yoon …peer-reviewed
Identification and Evaluation of Galleria mellonella Peptides with Antileishmanial ActivityPeer ReviewedIsabel A. Patiño-Márquez; Edwin Patiño-González; Laura Hernández-Villa; Blanca Ortíz-Reyes; Marcela Manrique-Morenopeer-reviewed
Effects of Plant Species on Stream Bacterial Communities via Leachate from Leaf LitterPeer ReviewedAdam S. Wymore; Elena Salpas; Giorgio Casaburi; Cindy M. Liu; Lance B. Price; Bruce A. Hungate; William H. McDowell; Jane C. Markspeer-reviewed
Hydrophilic Interaction Liquid Chromatography in the Separation of Glycopeptides and their IsomersPeer ReviewedPetr Kozlik; Radoslav Goldman; and Miloslav Sandapeer-reviewed
Integrated Stress Response and Decreased ECM in Cultured Stromal Cells from Keratoconus CorneasPeer ReviewedJames W. Foster; Vishal Shinde; Uri S. Soiberman; Gajanan Sathe; Sheng Liu; Julius Wan; Jiang Qian; Yassine Dauoud; Akhilesh Pandey; Albert S. Jun; Shukti Chakravartipeer-reviewed
Effects of Elevated Hydrostatic Pressure against Mesophilic Background Microflora and Habituated Salmonella Serovars in Orange JuiceFood ScienceAbimbola Allison1; Edward Daniels1; Shahid Chowdhury1,2 and Aliyar Fouladkhah1,2,* Microorganisms 2018, 6, 23 | https://doi.org/10.3390/microorganisms6010023food-science
Multi-Region Proteome Analysis Quantifies Spatial Heterogeneity of Prostate Tissue BiomarkersPCT-HD (PCT-SWATH)Tiannan Guo; Li Li; Qing Zhong; Niels J Rupp; Konstantina Charmpi; Christine E Wong; Wagner; Jan H Rueschoff; Wolfram …pct-hd-pct-swath
Identification of Protein Abundance Changes in Biopsy-Level Hepatocellular Carcinoma Tissues Using PCT-SWATHPeer ReviewedYi Zhu; Jiang Zhu; Cong Lu; Ping Sun; Wei Xie; Qiushi Zhang; Yue Liang; Tiansheng …peer-reviewed
Deep proteome mining of FFPE tissue with PASEF technologyKratika Singhala; Chris M. Adamsb; Ryan D. Leiba; Allis S. Chiena aStanford University Mass Spectrometry, …
Slide Presentation: High Pressure Proteolysis – A Highly Efficient Technique for Antibody Epitope Elucidation by Proteolytic Excision Affinity- Mass SpectrometryMichael Przybylski Steinbeis Centre for Biopolymer Analysis & Biomedical Mass Spectrometry, Rüsselsheim am Main, Germany
Abstract: New Perspectives for Protein Immunotherapy and Vaccine Development through Antibody Epitope Identification using Affinity- Mass spectrometryMichael Przybylski1,2; Loredana Lupu1,2; Pascal Wiegand1,5; Zdenek Kukacka1; Yannick Baschung1; Friedemann Völklein2; Alexander Lazarev3; Anna …
High Pressure-Accelerated Digestion of Unreduced IgG by Lys-C and TrypsinVera Gross; Nicole Cutri; Gary Smejkal; Alexander Lazarev Pressure BioSciences, Inc., 14 Norfolk Ave., South …
High Pressure Optical Spectroscopy and Real-Time Enzyme Kinetics: II. The Effects of High Pressure, Temperature, and Solvent on Lysyl Endoproteinase ActivityINTRODUCTION The rate, specificity, and efficiency of proteolytic digestion profoundly impact bottom-up mass spectrometry analysis …
Proteogenomics: Redefining the Approach for Precision MedicineDr. Thomas A. Conrads
Pressure BioSciences, Inc. Reports Fourth Quarter and Fiscal Year 2017 Financial Results and Provides Business Update
Pressure BioSciences, Inc. Reports Fourth Quarter and Fiscal Year 2017 Financial Results and Provides Business Update
Fourth Quarter and Fiscal Year 2017 Financial Results Conference CallSOUTH EASTON, MA / ACCESSWIRE / March 29, 2018 / Pressure BioSciences, Inc. (OTCQB: PBIO) (“PBI” …
Pressure Cycling-Accelerated Digestion with Trypsin: Protein Modifications and Enzyme SpecificityIntroduction Here we report that 90 minute pressure-accelerated trypsin digestion of whole tissue lysate is …
High Pressure-Accelerated Lys-C Digestion in the HUB880 Explorer: Rapid Digestion of Unreduced IgG Part III. Effects of Urea and Sodium DeoxycholateIntroduction The benefit of high pressure incubation for enhanced Lys-C digestion of unreduced IgG, and …
High Pressure-Accelerated Lys-C Digestion in the HUB880 Explorer: Rapid Digestion of Unreduced IgG Part II. Effect of Acetonitrile, N-Propanol, and MethanolIntroduction The benefit of high pressure incubation for enhanced Lys-C digestion of unreduced IgG, and …
High Pressure-Accelerated Lys-C Digestion in the HUB880 Explorer: Rapid Digestion of Unreduced IgG Part IIntroduction The goal of the current Application Note is to provide the best set of …
Effects of Elevated Hydrostatic Pressure against Mesophilic Background Microflora and Habituated Salmonella Serovars in Orange JuicePeer ReviewedAbimbola Allison1; Edward Daniels1; Shahid Chowdhury1,2; Aliyar Fouladkhah1,2,* 1Public Health Microbiology Laboratory, Tennessee State University, Nashville, TN 37209, …peer-reviewed
High Pressure-Accelerated PNGase F Deglycosylation of Native ProteinsVera Gross; Nicole Cutri; Alexander LazarevPressure BioSciences, Inc., 14 Norfolk Ave. South Easton MA 02375 …
High Pressure Denaturation Improves Protein Digestion by TrypsinVera Gross; Nicole Cutri; Gary Smejkal; and Alexander LazarevPressure BioSciences, Inc., 14 Norfolk Ave, South …
High Pressure Denaturation Improves Protein Digestion by Trypsin/Tips and Tricks TalkVera Gross, PhD Pressure BioSciences, Inc., South Easton MA, USA
Pressure BioSciences, Inc. CEO, Ric Schumacher, Rejoins “Stock Dayâ€_x009d_, Very Optimistic About His Company’s Growth and Success in 2018 and BeyondMr. Richard T. Schumacher, CEO and President of Pressure BioSciences, Inc. (OTCQB:PBIO) (the “Companyâ€_x009d_) returns …
Pressure BioSciences, Inc. and ISS, Inc. Announce Two-Year Worldwide Co-Marketing and Distribution AgreementISS High Pressure Optical Cell Integrated with PBI Automated High Pressure Instrument: Combination Results in Unique …
Mitochondrial Function and Sirtuin Expression in Hippocampus of Young and Old High and Low-Capacity Runner Rats. Master’s ThesisMitochondriaKontro Hmitochondria
Dietary Betaine Supplementation Increases Fgf21 Levels to Improve Glucose Homeostasis and Reduce Hepatic Lipid Accumulation in MicePeer ReviewedEjaz A; Martinez-Guino L; Goldfine AB; Ribas-Aulinas F; De Nigris V; Ribó S; Gonzalez-Franquesa A; …peer-reviewed
Mitochondrial GSH Replenishment as a Potential Therapeutic Approach for Niemann Pick Type C DiseasePeer ReviewedTorres S; Matías N; Baulies A; Nuñez S; Alarcon-Vila C; Martinez L; Nuño N; Fernandez …peer-reviewed
Sex-Specific Differences in Mitochondria Biogenesis, Morphology, Respiratory Function, and ROS Homeostasis in Young Mouse Heart and BrainPeer ReviewedKhalifa AR; Abdel-Rahman EA; Mahmoud AM; Ali MH; Noureldin M; Saber SH; Mohsen M; Ali …peer-reviewed
Hepatic Effects of Pharmacological Doses of Hydroxy-Cobalamin[c-lactam] in MicePeer ReviewedHaegler P; Grünig D; Berger B; Terracciano L; Krähenbühl S; Bouitbir Jpeer-reviewed
High-Pressure Spectroscopy (HPS) and Enzyme Kinetics: The Synergistic Effect of High pressure and Temperature on Trypsin, Chymotrypsin, and Lysyl Endopeptidase Digestion RatesGary Smejkal; Vera Gross; Nicole Cutri; Alexander Lazarev* Pressure BioSciences, Inc., 14 Norfolk Ave. South …
Proteomic Stratification of HPV(+) Oropharyngeal Squamous Cell Carcinoma Identifies Targets in Insulin Receptor Signaling within NonrespondersPeer ReviewedAaron Robinson; Sarah J. Parker; Shiao L. Stephen; Beatrice S. Knudsen; Zachary S. Zumsteg; Jennifer …peer-reviewed
Examining the Influence of Specificity Ligands and ATP-Competitive Ligands on the Overall Effectiveness of Bivalent Kinase InhibitorsPeer ReviewedMargaret L. Wong; Jason Murphy; Edmund Harrington; Carrie M. Gower; Rishi K. Jain; Markus Schirle; Jason R. Thomas  peer-reviewed
Application of SWATH Proteomics to Mouse BiologyPeer ReviewedYibo Wu1; Evan G. Williams1; Ruedi Aebersold1,2 1Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, …peer-reviewed
Pressure Dependence of Side Chain 13C Chemical Shifts in Model Peptides Ac-Gly-Gly-Xxx-Ala-NH2Markus Beck Erlach; Joerg Koehler; Edson Crusca, Jr.; Claudia E. Munte; Masatsune Kainosho; Werner Kremer; Hans Robert Kalbitzer Journal of Biomolecular NMR volume 69 | pages53–67(2017) | https://doi.org/10.1007/s10858-017-0134-5
Quantification of Cotinine in Dried Blood Spots as a Biomarker of Exposure to Tobacco SmokePeer ReviewedDaniel Ladrora; Bruce Pittb and William Funka aDepartment of Preventive Medicine, Feinberg School of Medicine, …peer-reviewed
A Photoaffinity Labeling-Based Chemoproteomics Strategy for Unbiased Target Deconvolution of Small Molecule Drug CandidatesProteomicsJason R. Thomas; Scott M. Brittain; Jennifer Lipps; Luis Llamas; Rishi K. Jain; Markus Schirle Novartis Institutes for Biomedical Research Cambridge USAproteomics
Pressure Cycling-Accelerated Digestion with Trypsin: Effect of Urea on Digestion at PressureIntroduction The positive effect of Pressure Cycling Technology (PCT) on digestion with trypsin is well …
Pressure-Accelerated Native Protein Deglycosylation by PNGase F EnzymeIntroductionThe positive effect of Pressure Cycling Technology (PCT) on digestion with trypsin is well established …
Pressure Cycling-Accelerated Digestion with Trypsin: Digestion of Native Proteins in Whole Tissue LysateIntroductionThe positive effect of Pressure Cycling Technology (PCT) on digestion with trypsin is well established …
Pressure-Based Alkaline Lysis with Immunocapture, a Method for Enhanced Recovery in Differential ExtractionPeer ReviewedVanesa Marinez; Deepthi Nori; Pero Dimimsoski; and Bruce McCord Department of Chemistry and Biochemistry, Florida International …peer-reviewed
Multiplex and Label-Free Relative Quantification Approach for Studying Protein Abundance of Drug Metabolizing Enzymes in Human Liver Microsomes Using SWATH-MSPeer ReviewedRohitash Jamwal;† Benjamin J. Barlock;† Sravani Adusumalli;† Ken Ogasawara;† Brigitte L. Simons;‡and Fatemeh Akhlaghi*;††Clinical Pharmacokinetics …peer-reviewed
An Adductomics Pipeline for Untargeted Analysis of Modifications to Cys34 of Human Serum AlbuminPeer ReviewedHasmik Grigoryan1; William Edmands1; Sixin S. Lu1; Yukiko Yano1; Luca Regazzoni1; Anthony T. Iavarone2; Evan …peer-reviewed
Using Lysine Adducts of Human Serum Albumin to Investigate the Disposition of Exogenous Formaldehyde in Human BloodPeer ReviewedLuca G. Regazzoni1; Hasmik Grigoryan1; Zhiying Ji1; Xi Chen2; Sarah I. Daniels1; Deyin Huang3; Sylvia …peer-reviewed
Profiling the Serum Albumin Cys34 Adductome of Solid Fuel Users in Xuanwei and Fuyuan, ChinaPeer ReviewedSixin S. Lu†; Hasmik Grigoryan¶; William M.B. Edmands¶; Wei Hu§; Anthony T. Iavaroneâ•‘; Alan Hubbard‡; …peer-reviewed
Cosolvent and Crowding Effects on the Temperature and Pressure Dependent Conformational Dynamics and Stability of Globular ActinPeer ReviewedSchummel PH; Haag A; Kremer W; Kalbitzer HR; Winter R J PHYS CHEM B | 2016 Jul 14;120(27):6575-86 | doi: 10.1021/acs.jpcb.6b04738 …peer-reviewed
Pressure Dependence of Backbone Chemical Shifts in the Model Peptides Ac-Gly-Gly-Xxx-Ala-NH2Peer ReviewedMarkus Beck Erlach; Joerg Koehler; Edson Crusca Jr.; Werner Kremer; Claudia E. Munte; Hans Robert …peer-reviewed
Characterizing the Escherichia coli O157:H7 Proteome Including Protein Associations with Higher Order AssembliesPeer ReviewedRembert Pieper; Quanshun Zhang; David J. Clark; Shih-Ting Huang; Moo-Jin Suh; John C. Braisted; Samuel …peer-reviewed
Transcriptome-Based Differentiation of Closely-Related Miscanthus LinesPeer ReviewedPhilippe Chouvarine; Amanda M. Cooksey; Fiona M. McCarthy; David A. Ray; Brian S. Baldwin; Shane …peer-reviewed
Fluctuations in Species-Level Protein Expression Occur during Element and Nutrient Cycling in the SubsurfacePeer ReviewedMichael J. Wilkins; Kelly C. Wrighton; Carrie D. Nicora; Kenneth H. Williams; Lee Ann McCue; …peer-reviewed
Proteogenomic Analysis of a Thermophilic Bacterial Consortium Adapted to Deconstruct SwitchgrassPeer ReviewedPatrik D’haeseleer; John M. Gladden; Martin Allgaier; Patrik S. G. Chain; Susannah G. Tringe; Stephanie …peer-reviewed
High-Resolution Physicochemical Characterization of Different Intravenous Immunoglobulin ProductsPeer ReviewedNathaniel Washburn; 1 Robin Meccariello; 1 Shaohui Hu; 2 Maurice Hains; 1 Naveen Bhatnagar; 1 Hetal Sarvaiya; …peer-reviewed
High-Throughput Proteomic Analysis of Fresh-Frozen Biopsy Tissue Samples Using Pressure Cycling Technology Coupled with SWATH Mass SpectrometryPCT-HD (PCT-SWATH)Yi Zhu and Tiannan Guo Institute of Basic Medical Sciences, Westlake Institute for Advanced Study Hangzhou People’s …pct-hd-pct-swath
Isolation of Mitochondrial DNA from Single, Short Hairs without Roots Using Pressure Cycling TechnologyForensicsKathryn A. Harper1; Kelly A. Meiklejohn1; Richard T. Merritt2;  Jessica Walker3; Constance L. Fisher4; James M. Robertson5   1Counterterrorism and …forensics
Extraction of RNA from Plant TissueArchived Publications and Postersarchived-publications-and-posters
Extraction of DNA from Plant Tissue Using Pressure Cycling Technology (PCT)Archived Publications and Postersarchived-publications-and-posters
Processing Bacillus Vegetative Cells and Spores Using Pressure Cycling Technology (PCT)Archived Publications and PostersBioterrorism remains an ever-present threat to the world. Rapid detection systems are critical to civilian …archived-publications-and-posters
Pressure Cycling Technology Sample Preparation System (PCT SPS) Improves Quantification of Pathogen DNA in Plants and SoilArchived Publications and PostersPatricia Okubara1, Chunqin Li2, Kurtis Schroeder1, and Nathan Lawrence21 USDA ARS, Root Disease & Biological …archived-publications-and-posters
Mechanical Loading-Induced TGF-β1 Mediates Cartilage Degradation Caused by Upregulation of HTRA1/DDR2Archived Publications and PostersLi, YF;1§ Li, Y;2* Xu, L;1* Servais, J;1 Frank, E;2 Lazarev, A;3 Olsen, BR;1 Grodzinsky, …archived-publications-and-posters
Improved Protein Recovery from Rat Pancreas Tissue Using Pressure Cycling Technology (PCT) and the ProteoSolve-SB KitProteomics Application NotesIntroductionPancreatic cancer has a very high mortality rate, primarily due to the fact that it …proteomics-application-notes
Total Protein Extraction from Small Tissue Samples Using PCT MicroTubes and the ProteoSolve-SB KitProteomics Application NotesExtraction of total proteins from tissue has generally been limited by the poor solubility of …proteomics-application-notes
Proteolysis-PrEP: Pressure-Accelerated Protein Digestion by Thermolysin EnzymeIntroductionThe positive effect of Pressure Cycling Technology (PCT) on digestion with trypsin is well established …
Proteolysis-PrEP: Pressure-Accelerated Activity of Elastase EnzymeIntroductionThe positive effect of Pressure Cycling Technology (PCT) on trypsin digestion is well established [1-4], …
Development of a Novel Culture-Independent Method for Comprehensive Detection and Identification of Beer-Spoilage MicroorganismsFood ScienceMasaki Shimokawa1; Kazumaru Iijima1; Yasuo Motoyama1; Koji Suzuki1; Hiromi Yamagishi1 1Asahi Breweries, Ltd., Moriya, Japanfood-science
Application of Elevated Hydrostatic Pressure for Inactivation of Wild-Type and Rifampicin-Resistant Phenotypes of Cronobacter sakazakiiFood ScienceEleonora Troyanovskaya; Abimbola Allison; Shahid Chowdhury; and Aliyar Fouladkhah Public Health Microbiology Laboratory, Tennessee State …food-science
Inactivation of Planktonically Grown Habituated Salmonella Serovars Through Application of Elevated Hydrostatic PressureFood ScienceAbimbola Allison   Advisor: Dr. Aliyar Fouladkhah Tennessee State University, Public Health M icrobiology Laboratory, College …food-science
Synergistic Effect of Heat and Elevated Hydrostatic Pressure for Inactivation of Listeria monocytogenesFood ScienceAbimbola Allison; Eleonora Troyanovskaya; Shahid Chowdhury; and Aliyar Fouladkhah Public Health Microbiology Laboratory, Tennessee State …food-science
High Pressure Processing for Decontamination of Orange Juice from Natural Flora and Salmonella serovarsFood ScienceAbimbola Allison; Eleonora Troyanovskaya; Shahid Chowdhury; Aliyar Fouladkhah   Public Health Microbiology Laboratory, Tennessee State …food-science
Guidelines for Protocol Development:Proteomics Application NotesIntroduction Pressure-enhanced proteolytic digestion exploits the ability of high hydrostatic pressure to promote protein denaturation …proteomics-application-notes
Evaluation of Pressure Cycling Treatment on Barocycler® NEP3229 for Extraction of Low-Template Forensic DNA SamplesForensicsMary Thompson, MS, F-ABC; Rebecca Schultheiss Mikulasovich, MS; Mark Powell, MS, F-ABC; Michael Donley, MS, …forensics
Super Absorbent Lower-Layers of Sanitary Pads: A Challenge in Sexual Aggression CasesForensicsInês Gregório1,2 and Pilar Martínez1 1National Institute of Toxicology & Forensic Science (INTCF), José Echegaray 4, …forensics
Rapid Processing of Archival Tissue Samples for Proteomic Analysis Using Pressure-Cycling TechnologyPeer ReviewedVinuth N. Puttamallesh1,2; Krishna Patel1,2 and Harsha Gowda1,3,*1Institute of Bioinformatics, International Tech Park, Bangalore 560066, …peer-reviewed
Evaluation of Pressure Cycling Treatment on Barocycler’ NEP3229 for Extraction of Low-Template Forensic DNA SamplesArchived Publications and PostersHarris County Institute of Forensic Sciences 1885 Old Spanish Trail Houston, TX 77054archived-publications-and-posters
Inactivation of Endogenous Tissue Proteases by BriefVera Gross; Nicole Cutri; Gary Smejkal; Alexander Lazarev   Pressure BioSciences, Inc., South Easton, MA, …
Streamlining PCT-HD for Tissue Biopsy Samples: Better Digestion in a Shorter Time.ASMS 2017Vera Gross1; Keith Ashman2; Peter Hains3; Alexander Lazarev1 1Pressure BioSciences, Inc., 14 Norfolk Ave., South …asms-2017
Fast and Efficient Non-Reduced Lys-C Digest Using Pressure Cycling Technology for Antibody Disulfide Mapping by LC-MSYing Cheng*; Yonghong Chen; Christopher Yu Protein Analytical Chemistry, Genentech Inc., 1 DNA Way, South San …
Compatibility of Deoxycholate Detergent with Pressure-enhanced Digestion by Trypsin and Lys-C: Alternative PCT-HD WorkflowHigh hydrostatic pressure accelerates protein digestion via a combination of two mechanisms. The first is …
SWATH® For Quantitative ProteomicsASMS 2017Randy Arnold, PhD – SCIEX Pressure Biosciences ASMS Breakfast Seminar, June 6, 2017asms-2017
PCT-Assisted Digestion for Tissue Proteomic Biomarker DiscoveryASMS 2017Thomas P. Conrads, Ph.D. Associate Director of Scientific TechnologiesInova Schar Cancer InstituteChief Scientific OfficerGynecologic Cancer …asms-2017
Discovery Starts With Sample Preparation-ASMS 2017ASMS 2017Dr. Alexander Lazarev, V.P. R&D Pressure BioSciences, Inc.asms-2017
High Pressure Activation of the Mrr Restriction Endonuclease in Escherichia coli Involves Tetramer DissociationAnaıs C. Bourges1,2,†; Oscar E. Torres Montaguth3,†; Anirban Ghosh3; Wubishet M. Tadesse3; Nathalie Declerck2; Abram …
Slides: PCT-HD for Tissue Biopsy Samples: Comparison to a Standard MethodVera Gross1; Peter Hains3; Keith Ashman2; Val Valova3; Alexander Lazarev1 1Pressure BioSciences, Inc., South Easton …
Booth Poster: PCT-SWATH Work Flow with the Barocycler 2320EXT~4 Hours from Tissue to Peptides PCT-SWATH was developed by PBI scientists and engineers in …
Booth Poster: Barocycler® 2320EXT Ideal for PCT-SWATHThe Barocycler 2320EXT  Pressure Range: ambient – 45,000psi (310 MPa)  Max Temperature: 95ËšC  Min Temperature: …
Cys34 Adducts of Reactive Oxygen Species in Human Serum AlbuminPeer ReviewedHasmik Grigoryan; He Li; Anthony T. Iavarone; Evan R. Williams; and Stephen M. Rappaportpeer-reviewed
Quantitative Proteomics Signature Profiling Based on Network ContextualizationPeer ReviewedWilson Wen Bin Goh; Tiannan Guo; Ruedi Aebersold and Limsoon Wongpeer-reviewed
Model HUB440 and HUB880 Advanced High Pressure Generators Fields of UsePressure BioSciences
Model HUB440 and HUB880 Advanced High Pressure Generators Current User ApplicationsPressure BioSciences, Inc.
Pressure Induced SOS Response in Escherichia coli Involves Mrr, a Restriction EndonucleaseFood ScienceAnaïs Bourges1,2, Oscar E. Torres M.3, Anirban Ghosh3, Wubishet M. Tadesse3, Gilles Labesse2, Nathalie Declerck2, …food-science
Intrinsic Allosteric Inhibition of Signaling Proteins by Targeting Rare Interaction States Detected by High-Pressure NMR SpectroscopyPeer ReviewedProf. Dr. Hans Robert Kalbitzer; Dr. Ina C. Rosnizeck; Prof. Dr. Claudia E. Munte; Dr. Sunilkumar Puthenpurackal …peer-reviewed
Reducing a Pathogen of Public Health Concern through Application of Elevated Hydrostatic PressureFood ScienceE. Daniels; S. Chowdhury; A. Fouladkhah POSTER | MEHARRY | NOVEMBER 10-11, 2016 | NASHVILLE, …food-science
Improved Extraction of Rhizoctonia and Pythium DNA from Wheat Root and Soil Samples Using Pressure Cycling TechnologyPeer ReviewedPatricia A. Okubara; Chunqin Li; Kurtis Schroeder; Richard T. Schumacher; and Nathan P. Lawrence  peer-reviewed
Rapid Release of N-Linked Glycans from Glycoproteins by Pressure-Cycling TechnologyPeer ReviewedZoltan Szabo; András Guttman and Barry L. Karger* Barnett Institute, Northeastern University, Boston, Massachusetts 02115peer-reviewed
Proteolysis-PrEP: Optimization of Pressure Cycling Conditions for Efficient Digestion of Native IgGIntroduction PCT has been proven to accelerate enzymatic protein digestion and the positive effect of …
Proteolysis-PrEP: Activity and Specificity of Chymotrypsin Under Pressure Cycling ConditionIntroductionPressure Cycling Technology (PCT) has been proven to accelerate enzymatic protein digestion. The positive effect …
Improved Proteolytic Digestion Under High Pressure Cycling: Rapid Digestion with Improved Sensitivity and Sequence CoverageArchived Publications and PostersVera Gross1; John Wilson2; Alexander Lazarev1 1Pressure BioSciences, Inc. Medford, MA; 2Protifi, LLC, Huntington, NY. …archived-publications-and-posters
Proteolysis-PrEP: Pressure-accelerated Activity of Endoproteinase Glu-CIntroductionThe positive effect of Pressure Cycling Technology (PCT) on trypsin digestion is well established [1-6], …
Under PressureConstant Systems
Comparative Lysis Efficiency of Saccharomyces cerevisiae at 40 kpsiConstant Systems
Comparative Lysis Efficiency of Escherichia coliConstant Systems
O2k-Fluorometry: HRR and H2O2 Production in Mouse Cardiac Tissue HomogenateMitochondriaEigentler A1; Fontana-Ayoub M2; Gnaiger E1,21D. Swarovski Research Lab, Dept Visceral, Transplant and Thoracic Surgery, …mitochondria
Grape Powder Improves Age-Related Decline in Mitochondrial and Kidney Functions in Fischer 344 RatsPeer ReviewedIndira Pokkunuri;1 Quaisar Ali;2 and Mohammad Asghar1 1Heart and Kidney Institute, Pharmacological and Pharmaceutical Sciences, …peer-reviewed
Various Constant Systems Publications and ApplicationConstant Systems Cell Disruptors are highly utilised by research groups in the areas of drug …
Streamlined Hands-Free Sample Preparation Using Pressure Cycling and PCT μPestle Sample Containers for Tissue Biopsy Profiling by SWATH-MSArchived Publications and PostersVera Gross1; Keith Ashman2; Peter Hains3; Alexander Lazarev*,1; Chris Hodgkins2; Phil Robinson3 1Pressure BioSciences, Inc., …archived-publications-and-posters
Method Development for Fecal Lipidomics ProfilingPeer ReviewedKatherine E. Gregory;†,‡ Susan S. Bird;§,∥ Vera S. Gross;⊥ Vasant R. Marur;§ Alexander V. Lazarev;⊥ W. Allan Walker;¶,â–² …peer-reviewed
High Pressure Induced DNA Damage in Escherichia coli Involves Pressure-Mediated Dissociation of the Tetrameric Mrr Restriction EndonucleasePeer ReviewedAnais Bourges; Anirban Ghosh; Nathalie Declerck; Abram Aertsen; Catherine Royer BIOPHYSICAL JOURNAL | VOLUME 110, ISSUE 3, SUPPLEMENT 1, 316A …peer-reviewed
Proteotypic Features of NCI-60 Cancer Cells Obtained by SWATH-MS Predicts PhenotypesPCT-HD (PCT-SWATH)Tiannan Guo*1; Ching Chiek Koh*1,2; Michael Menden*3; Alessandro Ori4; Murat Iskar4; Wilson Wen Bin Goh5; …pct-hd-pct-swath
Pressurized Pepsin Digestion in Proteomics: An Automatable Alternative to Trypsin for Integrated Top-Down Bottom-Up Proteomics*Daniel López-Ferrer; Konstantinos Petritis; Errol W. Robinson; Kim K. Hixson; Zhixin Tian; Jung Hwa Lee; …
Strategies to Recover Proteins from Ocular Tissues for ProteomicsArchived Publications and PostersPatel N1, Solanki E, Picciani R, Cavett V, Caldwell-Busby JA, Bhattacharya SK.  archived-publications-and-posters
Application of Pressurized Solvents for Ultrafast Trypsin Hydrolysis in Proteomics: Proteomics on the FlyDaniel López-Ferrer; Konstantinos Petritis; Kim K. Hixson; Tyler H. Heibeck; Ronald J. Moore; Mikhail E. …
Ultra-Rapid Pressure Digestion and Label-Free Quantitative Proteomics of Yersiniae Infected Mice TissuesArchived Publications and PostersKim K. Hixson1, Daniel López-Ferrer1, Matthew Bender2, Patricia L. Worsham3, Karl K. Weitz1, Nate Lawrence4, …archived-publications-and-posters
Rapid and Efficient Protein Digestion Using Trypsin-Coated Magnetic Nanoparticles Under Pressure CyclesPeer ReviewedLee B; Lopez-Ferrer D; Kim BC; Na HB; Park YI; Weitz KK; Warner MG; Hyeon …peer-reviewed
Revisiting Jurassic Park: The Isolation of Proteins from Amber Encapsulated Organisms Millions of Years OldArchived Publications and PostersGary B. Smejkal, et al.archived-publications-and-posters
Rapid Mass Spectrometric Conversion of Tissue Biopsy Samples into Permanent Quantitative Digital Proteome MapsPeer ReviewedTiannan Guo; Petri Kouvonen; Ching Chiek Koh; Ludovic C Gillet; Witold E Wolski; Hannes L Röst; George Rosenberger; Ben C …peer-reviewed
Digestion, Purification, and Enrichment of Protein Samples for Mass SpectrometryPeer ReviewedVictoria E. Hedrick; Mercedes N. LaLand; Ernesto S. Nakayasu; Lake N. Paulpeer-reviewed
High Pressure Induced DNA Damage in Escherichia Coli Involves Pressure-Mediated Dissociation of the Tetrameric Mrr Restriction EndonucleasePeer ReviewedAnais Bourges; Anirban Ghosh; Nathalie Declerck; Abram Aertsen; Catherine Royer BIOPHYSICAL JOURNAL | VOLUME 110, ISSUE 3, SUPPLEMENT 1, 316A …peer-reviewed
From PCT-HD to SWATH® Data Acquisition in Half a DayPCT-HD (PCT-SWATH)Vera Gross, Ph.D. Senior Scientistpct-hd-pct-swath
Elevated Pressure Improves the Rate of Formalin Penetration while Preserving Tissue MorphologyPeer ReviewedIngrid E. Chesnick1; Jeffrey T. Mason1; Timothy J. O’Leary2; Carol B. Fowler1,2 1Department of Biophysics, …peer-reviewed
Elevated Pressure Improves the Extraction and Identification of Proteins Recovered from Formalin-Fixed, Paraffin-Embedded Tissue SurrogatesPeer ReviewedCarol B. Fowler; Ingrid E. Chesnick; Cedric D. Moore; Timothy J. O’Leary; Jeffrey T. Masonpeer-reviewed
Improved Protein Extraction and Protein Identification from Archival Formalin-Fixed Paraffin-Embedded Human AortasForensicsFu Z; Yan K; Rosenberg A; Jin Z; Crain B; Athas G; Heide RS; Howard …forensics
Improved Protein Extraction and Protein Identification from Archival Formalin-Fixed Paraffin-Embedded Human AortasPeer ReviewedFu Z; Yan K; Rosenberg A; Jin Z; Crain B; Athas G; Heide RS; Howard …peer-reviewed
file_57c49bf97f377_ASMS2014_PBI-Corporate_FINAL.pdfArchived Publications and Postersarchived-publications-and-posters
file_57c49bf0e73d3_HPBB2014poster.pdfArchived Publications and Postersarchived-publications-and-posters
Gross-et-al-MSACL2014.pdfArchived Publications and Postersarchived-publications-and-posters
file_57c49be6da352_ASMS2014-Abstracts-Formatted.pdfArchived Publications and Postersarchived-publications-and-posters
Quantification of Cotinine in Plasma and Dried Blood Spots Using Nano-Chip LC-MSLadror, Daniel T.;1 Funk, William E.1 1Department of Preventive Medicine, Northwestern University Feinberg School of Medicine
Large-Scale Quantitative Proteomic Analysis Identifies Multiple Pathways In COPD-Associated Lung CancerB. Sandri, PhD1, A. Limper, MD2, P. Jagtap, PhD4, Y. Ping, MD2, C. Murie, PhD3, …
Stratification of Prostate Cancer Tissue Biopsy Samples using PCT-SWATHArchived Publications and PostersTiannan Guo1; Li Li2; Ulrich Wagner3; Qing Zhong3; Christine Fritz3; Christian Fankhauser3; Cedric Poyet3; Rebecca …archived-publications-and-posters
New Products from Pressure BioSciences for Enhanced Proteomic Sample PreparationPressure BioSciences, Inc. 14 Norfolk Ave., South Easton, MA
Improved Proteolytic Digestion Under High Pressure Cycling: Rapid Digestion with Improved Sensitivity and Sequence CoverageArchived Publications and PostersVera Gross1; John Wilson2; Alexander Lazarev1 1Pressure BioSciences, Inc. Medford, MA; 2Protifi, LLC, Huntingtonarchived-publications-and-posters
New Products from Pressure BioSciences for Enhanced ProteomicPressure BioSciences, Inc. 14 Norfolk Ave., South Easton, MA
PCT-SWATH Enables Industrial-Scale ProteomicsPCT-HD (PCT-SWATH)Project Leaders: Phil Robinson and Roger Reddel Children’s Medical Research Institute, Sydney, Australiapct-hd-pct-swath
Reproducible Protein Sample Preparation from Small Amount of Clinical Specimens for Proteomic StudiesArchived Publications and PostersTiannan Guo, MD, PhD Lab of Ruedi Aebersold at ETH Zurich 2016.6.28 Dortmund, Germanyarchived-publications-and-posters
PCT News May 2016
PCT News March 2016
PCT News June 2016
PCT News January 2016 Special Edition
PCT News January 2016
PCT News February 2016
PCT News August 2016
PCT News April 2016
Differential Extraction Using Alkaline Lysis and PressureForensicsDeepthi Nori and Bruce McCordforensics
The Application of Alkaline Lysis and Pressure Cycling Technology in the Differential Extraction of DNA from Sperm and Epithelial Cells Recovered from Cotton SwabsForensicsDeepthi V. Nori & Bruce R. McCordforensics
Proteomics Under Pressure: Development of Essential Sample Preparation Techniques in Proteomics Using Ultrahigh Hydrostatic PressureEmily Freeman and Alexander R. Ivanov* HSPH Proteomics Resource, Department of Genetics and Complex Diseases, …
Improved Proteomic Profiling of the Cell Surface of Culture-Expanded Human Bone Marrow Multipotent Stromal CellsSamuel T. Mindayea; Moonjin Raa; Jessica Lo Surdob; Steven R. Bauerb; Michail A. Altermana aTumor …
Site Specific Glycoforms of Haptoglobin in Liver Cirrhosis and Hepatocellular CarcinomaPetr Pompach1; Zuzana Brnakova1; Miloslav Sanda1; Jing Wu2; Nathan Edwards3; Radoslav Goldman4   1Department of …
Minimal Sample Requirement for Highly Multiplexed Protein Quantification in Cell Lines and Tissues by PCT-SWATH Mass SpectrometryPeer ReviewedShao S1,2; Guo T2; Koh CC2; Gillessen S3; Joerger M3; Jochum W4; Aebersold R2,5 1Division of Endocrinology, Tongji Hospital, Huazhong …peer-reviewed
Reproducible Tissue Homogenization and Protein Extraction for Quantitative Proteomics using MicroPestle-assisted Pressure Cycling TechnologyPeer ReviewedShao S; Guo T; Gross V; Lazarev A; Koh CC; Gillessen S; Joerger M; Jochum W; Aebersold Rpeer-reviewed
Improved Protocols for Isolation of Intact Mitochondria from Tissue Samples
Improved Extraction of Biomolecules from Plants, Animals, and Fungi with the PCT ShredderArchived Publications and Postersarchived-publications-and-posters
Optimization of Rapid Protein Digestion Using PCT
An Integrated Sample Prep Workflow Provides Results in Hours: Combining PCT and Parallel Isoelectric Focusing
Optimization of High Pressure-Assisted Methods for Proteomic Sample PrepArchived Publications and PostersAlexander V. Lazarev1*; Vera S. Gross1; Greta Carlson1; Edmund Ting1; Emily Freeman2; Alexander R. Ivanov2; …archived-publications-and-posters
Tissue Fractionation by Hydrostatic PCT: The Unified Sample Prep Technique for Systems Biology StudiesArchived Publications and PostersVera Gross,1 Greta Carlson,1 Ada T Kwan,1 Gary Smejkal,1 Emily Freeman,2 Alexander R Ivanov,2 Alexander …archived-publications-and-posters
Complete Disruption of Caenorhabditis elegans Under Non-Denaturing Conditions Using PCTArchived Publications and Postersarchived-publications-and-posters
Multiplex Biomolecule Extraction Using the PCT Sample Prep SystemArchived Publications and Postersarchived-publications-and-posters
Proteomics Under Pressure: Rapid Extraction and Digestion in a Single TubeArchived Publications and PostersAlexander V. Lazarev1; Emily Freeman2; Vera S. Gross1; Greta Carlson1; Edmund Ting1; Alexander R. Ivanov2 …archived-publications-and-posters
Simple Protocols for Isolation of Intact Mitochondria using The Shredder SG3 and PBI Mitochondria Isolation Kits
Isolation of Proteins from Small Subcutaneous Murine Tumor and Adipose Tissues Using PCTArchived Publications and Postersarchived-publications-and-posters
Elucidation of the Frankia EAN1pec Genome Sequence Shows Gene Expansion and Metabolic Versatility
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Tisa_SouthAfrica_N2Fix_Jan25_2007.ppt
Biological Sample Extraction Using PCTArchived Publications and Postersarchived-publications-and-posters
Proteomic Analyses of Proteins Isolated From Mammalian Bone Using PCTArchived Publications and Postersarchived-publications-and-posters
Applications of PCT to Sample Prep for Two-Dimensional Gel ElectrophoresisArchived Publications and Postersarchived-publications-and-posters
The Evolution of Sample Prep in Proteomics: Applications of PCT Spanning from Bacteria to Homo sapiensArchived Publications and Postersarchived-publications-and-posters
Introduction of a Bench Top Instrument Employing PCT for the Extraction of Nucleic Acids and ProteinsArchived Publications and Postersarchived-publications-and-posters
Microtubule Associated Proteins and Motor Molecules: Direct Tissues MALDI Identification and ImagingArchived Publications and Postersarchived-publications-and-posters
Targets: Innovations in Genomics and ProteomicsArchived Publications and Postersarchived-publications-and-posters
PCT: A Novel Approach to Virus Inactivation in PlasmaArchived Publications and Postersarchived-publications-and-posters
Unusual Properties of Highly Charged Buffers: Large Ionization Volumes and Low Barrier Hydrogen BondsArchived Publications and Postersarchived-publications-and-posters
Use of High Pressure to Accelerate Antibody-Antigen Binding Kinetics Demonstrated in an HIV-1 p24:Anti-HIV-1 p24 AssayArchived Publications and Postersarchived-publications-and-posters
High Pressure Mediated Dissociation of Immune Complexes Demonstrated in Model SystemsArchived Publications and Postersarchived-publications-and-posters
Use of PCT for the Release of DNA from PlantsArchived Publications and Postersarchived-publications-and-posters
PCT Mediated Sample Preparation Schemes Enabling High Quality Two-Dimensional Gel Electrophoresis of Fagus grandifolia Tree Bark ProteinsArchived Publications and Postersarchived-publications-and-posters
PCT Sample Prep System Improves Quantification of Pathogen DNA in Plants and SoilArchived Publications and Postersarchived-publications-and-posters
A Comparison of PCT to Other Methods for Protein ExtractionArchived Publications and Postersarchived-publications-and-posters
Novel Bacterial Protein Extraction for Proteomic AnalysisArchived Publications and Postersarchived-publications-and-posters
Proteome Society MeetingArchived Publications and Postersarchived-publications-and-posters
Electrophoretic Analyses of Proteins Isolated from Mammalian, Avian, and Reptilian Bone Using PCTArchived Publications and Postersarchived-publications-and-posters
Electrophoretic Analyses of Proteins and Peptides Isolated from Cortical Bone Using PCTArchived Publications and Postersarchived-publications-and-posters
Proteomic Analysis of Murine Adipose Tissue Using PCT and High Resolution Tandem Mass SpectrometryArchived Publications and Postersarchived-publications-and-posters
Applications of PCT to Sample Preparation for Proteomic Analyses by Two-Dimensional Gel Electrophoresis
PCT Mediated Sample Preparation Schemes for Isolating Proteins from the Nematode Caenorhabditis elegans
PCT Applications in Extraction of Biomolecules from Challenging Biological Samples
A New Bench Top System for Sample Preparation Using PCT
Deciphering the Mechanisms of Action in the Release of Molecules from Biological Samples Using PCT
Extraction of Nucleic Acids from Challenging Biological Samples Using PCT
HTP Proteome-Glycome Analysis in Caenorhabditis elegans
Proteomic Analysis of Individual Daphnia Microcrustaceans
Breaking the Tough Cuticle of Caenorhabditis elegans Using PCT and Optimized Lysis Reagents: Giving the Worms a Perm
Solution Phase Isoelectric Fractionation in the Multi-Compartment Electrolyser: A Divide and Conquer Strategy for the Analysis of Complex Proteomes
Deciphering Mechanisms for Infectious Agent Inactivation Using Cyclic High Pressure or PCT
Biomarker Profiles of Echinacea Species Using PCT and MALDI-TOF Mass Spectrometry
Proteomic Analysis of Adipose Tissue Using Detergent-Free Protein Extraction by PCT and High Resolution Tandem Mass Spectrometry
Inactivation of HIV-1 using PCT
Application of PCT in Proteomics: Increased Cell Lysis and Protein Yields from Model Organisms
A Novel Sample Prep Approach to Biomarker Discovery and Drug Development in Lipid Rich Samples
DNA_polymoliphism_Tokai_Japan.pdf
Improved DNA Profiles from Aged Horse Feces Using Pressure Cycling TechnologyPeer ReviewedK. Deshpande1,2; M. Villarreal1,2; D. K. Mills1,2 1Department of Biological Sciences, Florida International University, OE 167, …peer-reviewed
Tandem Mass Spectrometry Analysis of Ex Vivo Amyloid Fibril and Tissue SamplesArchived Publications and PostersZhenning Hong,1Giuseppe Infusini,1 Lawreen H. Connors,2 Martha Skinner,2 Catherine E. Costello1,2 1Mass Spectrometry Resource and …archived-publications-and-posters
Integral Membrane Protein Extraction and Biomarker Analysis from Solid Metastatic Ovarian TumorsArchived Publications and PostersL.V. Schneider1, V. Likhte1, W. Wright1, F. Chu1, E. Cambron1, A. Baldwin1, J. Krakow1, A. …archived-publications-and-posters
Comparative Proteomic Analysis of Human Embryonic Stem Cells (hESCs) and Human Induced Pluripotent Stem Cells (hiPSCs) of Different OriginArchived Publications and PostersNatalia Pripuzova, Melkamu Getie-Kebtie, Christopher Grunseich, Colin Sweeney, Harry Malech and Michail Alterman Tumor Vaccine …archived-publications-and-posters
Soluble Forms of the Notch Ligands Delta1 and Jagged1 Promote in Vivo Tumorigenicity in NIH3T3 Fibroblasts with Distinct PhenotypesArticlesSumithra Urs, Alice Roudabush, Christine F. O�Neill, Ilka Pinz, Igor Prudovsky, Doreen Kacer, Yuefang Tang, …articles
Mass Spectrometry-Based Proteomic Quest for Diabetes BiomarkersArchived Publications and PostersShiying Shao a,b, Tiannan Guo b, Ruedi Aebersold b,c, a Division of Endocrinology, Tongji Hospital, …archived-publications-and-posters
Development of High Hydrostatic Pressure in Biosciences: Pressure Effect on Biological Structures and Potential Applications in BiotechnologiesArchived Publications and PostersNolwennig Rivalaina,c, Jean Roquainb,c, G�rard Demazeaua,c ICMCB-CNRS � Universit� de Bordeaux � 87, avenue du …archived-publications-and-posters
A Proteomics Jurassic Park: The Isolation of Proteins from Microorganisms Encapsulated in Amber from the Oligo-Miocene Epoch 30-40 Million Years AgoArchived Publications and PostersGary B. Smejkal1,3, George O. Poinar Jr.2, Feixia Chu3 and Pier Giorgio Righetti4 1 Harvard …archived-publications-and-posters
Digestion with Pressure Cycling Technology (PCT)Archived Publications and PostersNicholas Sobol, Jennifer Oprihory*, Tiffany Remsen, A. Yuen, P., Paul Pevsner. Department of Pathology and …archived-publications-and-posters
Rapid Protein Extraction and Trypsin Digestion with Pressure Cycling Technology (PCT)Archived Publications and PostersPaul H Pevsner et al., University of Missouri School of Medicinearchived-publications-and-posters
Exploring Simvastatin, an Antihyperlipidemic Drug, as a Potential Topical Antibacterial AgentPeer ReviewedShankar Thangamani1; Haroon Mohammad1; Mostafa F.N. Abushahba1,2; Maha I. Hamed1,2;Tiago J. P. Sobreira3; Victoria E. …peer-reviewed
Evaluation of Pressure Cycling Treatment on Barocycler® NEP3229 for Extraction of Low-Template Forensic DNA SamplesArchived Publications and PostersMary Thompson, MS, F-ABC, Rebecca Schultheiss Mikulasovich, MS, Mark Powell, MS, F-ABC, Michael Donley, MS, …archived-publications-and-posters
Differential Extraction Using Alkaline Lysis and Pressure CyclingArchived Publications and PostersGreen Mountain Meeting Deepthi Nori and Bruce McCord Department of Chemistry and Biochemistry Florida International …archived-publications-and-posters
Applications of High Pressure for Automated High Performance Proteomics Capitalizing on Thermodynamic Principles to Reduce Sample Preparation Times from Hours to MinutesArchived Publications and PostersDaniel L�pez-Ferrer Caprion Proteomics US LLCarchived-publications-and-posters
Pressure Cycling Technology (PCT) Applications for Forensic DNA AnalysisArchived Publications and PostersPam Marshall, MS; Jonathan King, MS; Meredith Turnbough, PhD; Arthur J. Eisenberg, PhD; Bruce Budowle, …archived-publications-and-posters
Application of Pressure Cycling Technology (PCT) in Differential ExtractionArticlesDeepthi Nori, MFS** Bruce R. McCord, PhD International Forensic Research Institute, Department of Chemistry and …articles
Pressure Cycling Technology (PCT) Reduces Effects of Inhibitors of the PCRForensicsPamela L. Marshall1, Jonathan L. King1, Nathan P. Lawrence2, Alexander Lazarev2, Vera S. Gross2, Bruce …forensics
Improved Preparation and Analysis of Biothreat Agents and Infectious Microbial Samples Using Pressure Cycling Technology (PCT)ArticlesBradford Powell, Ph.D., Cernomics Solutionsarticles
Optimal Preparation of Difficult Samples for Systems BiologyArticlesBradford Powell Ph.D., PMP Cernomics Solutions ClinMicro-2012articles
Keynote: Microbe InactivationArticlesBradford Powell Ph.D., PMP Cernomics Solutions ClinMicro-2012articles
Development of Improved Sample Inactivation and Extraction Methods for Systems Biology AnalysisArticles1Bradford S. Powell and 2Loreen L. Lofts 1Bacteriology Division and 2Virology Division, U.S. Army Medical …articles
Mapping Protein Conformational Heterogeneity Under Pressure with Site-Directed Spin Labeling and Double Electron-Electron ResonanceArchived Publications and PostersMichael T. Lercha,b, Zhongyu Yanga, Evan K. Brooksa, and Wayne L. Hubbella,b,1 aJules Stein Eye …archived-publications-and-posters
Pressure Cycling Technology Research at UNTCHIArticlesElizabeth Fellerarticles
Mechanical Loading-Induced TGF-β1 Mediates Cartilage Degradation Caused by Upregulation of HTRA1/DDR2Archived Publications and PostersLi, YF;1, Li, Y;2* Xu, L;1* Servais, J;1 Frank, E;2 Lazarev, A;3 Olsen, BR;1 Grodzinsky, …archived-publications-and-posters
Label-Free Mass Spectrometry-Based Relative Guantitation of Proteins Separated by 1DEArchived Publications and PostersMelkamu Getie-Kebtie1; Maryna Eichelberger2, Manju B. Joshi13, Rajesh Gupta3, Michail A. Alterman1 1FDA/CBER/OCTGT/TVBB; 2FDA/CBER/OVRR/LPRVD; 3FDA/CBER/OVRR/PQLSarchived-publications-and-posters
The Global Proteomic Architecture of Culture-Expanded Human Bone Marrow Multipotent Stromal Cells and the Proteomic Basis of HeterogeneityArchived Publications and PostersSamuel T Mindaye*, Moonjin Ra*, Jessica Lo Surdo**, Steven Bauer**, Michail Alterman* CBER *Tumor Vaccines …archived-publications-and-posters
Recovery and Immunoaffinity Mass Spectrometric Analysis of Integral Membrane Proteins from Metastatic Ovarian Cancer Tissue Using PCT and ProteoSolve-TD BuffersArchived Publications and PostersDr. Luke V. Schneider, CSO, Target Discovery, Inc.archived-publications-and-posters
Tissue Homogenates for Diagnosis of Mitochondrial Respiratory Function: Mouse Heart, Brain and LiverArticlesAndrea Eigentler, Mona Fontana-Ayoub, and Erich Gnaiger Medical University of Innsbruck, Department of Visceral, Transplant …articles
PBI-Shredder HRR- Set: Preparation of Tissue Homogenates for Diagnosis of Mitochondrial Respiratory FunctionArticlesAnna Draxl, Andrea Eigentler, and Erich Gnaiger OROBOROS INSTRUMENTS Corp, Sch�pfstr 18, A-6020 Innsbruck, Austria. …articles
High-Pressure EPR Reveals Conformational Equilibria and Volumetric Properties of Spin-Labeled ProteinsArchived Publications and PostersJohn McCoy and Wayne L. Hubbell1 Jules Stein Eye Institute and Department of Chemistry and …archived-publications-and-posters
Pressure Cycling Technology (PCT): Applications for Forensic DNA AnalysisArchived Publications and PostersPam Marshall University of North Texas Health Science Center, Center for Human Identificationarchived-publications-and-posters
MALDI and LCMS Identifications of Early Protein and LA-ICP-MS Identification of Early Metal Biomarkers of Ionizing RadiationArticlesP. Pevsner1, G. Li2, N. Sobol1, D.C Miller1, D. Robertson2,3 1Department of Pathology and Anatomical …articles
Comparative Proteomics of Swine Tissue 2DLC/MS of Tissue Digestion Preliminary Protein AnalysisArticlesMatthew Lawrence Human Proteomics Program University of Wisconsin-Madisonarticles
High-Pressure Conformational Ensemble of Apomyoglobin Revealed by Double Electron-Electron ResonanceArchived Publications and PostersMichael Lerch, Zhongyu Yang, Evan Brooks, and Wayne L. Hubbell Jules Stein Eye Institute and …archived-publications-and-posters
MALDI and LCMS Protein Biomarkers of Ionizing RadiationArticlesTiffany Remsen, Vladamir Kachalov, Parth Kothiya, Zeineen A. Momin*, Naresh Vasani, Jason Chouake, Douglas C. …articles
The Best Approach: Homogenization or Manual Permeabilization of Human Skeletal Muscle Fibers for Respirometry?Archived Publications and PostersSteen Larsen a, Regitze Kraunsøe a, Martin Gram a, Erich Gnaiger b, Jørn W. Helge …archived-publications-and-posters
Role of luxS in Bacillus Anthracis Growth and Virulence Factor ExpressionArticlesMarcus B. Jones,1-3,* Scott N. Peterson,1 Rosslyn Benn,1 John C. Braisted,1 Behnam Jarrahi,1 Kenneth Shatzkes,1 …articles
DNA Extraction Methods for Acroalgal Ulva SpeciesArchived Publications and PostersGelin, S., Dostie, K., Bresemen, M., Battocletti, A., Thornber, C., Swanson, JD. 5th Annual RI …archived-publications-and-posters
Intrinsic Allosteric Inhibition of Signaling Proteins by Targeting Rare Interaction States Detected by High-Pressure NMR SpectroscopyArticlesHans Robert Kalbitzer,* Ina C. Rosnizeck, Claudia E. Munte, Sunilkumar Puthenpurackal Narayanan, Veronika Kropf, and …articles
Intact Protein Profiling and Deconvolution of Bacterial Lysates on Multiple Mass SpectrometersArchived Publications and PostersDenis Andrzejewski1; John H. Callahan1; Timothy Croley1; Peter E. Leopold2; Melinda A. McFarland1 1FDA-CFSAN, College …archived-publications-and-posters
Development of a 20 kpsi Enzymatic Digester for High Throughput Proteomic Analysis and Its Application to Membrane ProteomicsArchived Publications and PostersSeok-Won Hyung1; Daniel L�pez-Ferrer1; Daniel J. Orton1; Erika Zink1; Karl K. Weitz1; Rui Zhao1; Ronald …archived-publications-and-posters
The Proteomic Expression Program of Human Bone Marrow Multipotent Stromal Cells: Donor-to-Donor Heterogeneity and the Proteomic Changes During Cell PropagationArchived Publications and PostersSamuel T Mindaye*, Moonjin Ra*, Jessica Lo Surdo**, Steven Bauer**, Michail Alterman* *Tumor Vaccines and …archived-publications-and-posters
New Strategies for High Pressure-Assisted Digestion in ProteomicsArticlesKim K. Hixson1,2, Daniel L�pez-Ferrer1, Karl K. Weitz1, Ronald J. Moore1, Scott R. Kronewitter1, Heather …articles
High Pressure Direct Protein Extraction from Tissue – Trypsin Digest with Pressure Cycling Technology (PCT)ArticlesNicholas Sobol, Jennifer Oprihory*, Parth Kothiya, Zeineen A. Momin, Naresh Vasani, Vladamir Kachalov, Tiffany Remsen, …articles
High-Pressure Assisted In-Gel Tryptic Digestion for Qualitative and Quantitative Characterization of Protein MixturesArticlesMelkamu Getie-Kebtie and Michael Alterman FDA-CBER-NIH, Rockville Pike, HFM � 735 Bldg 29A rm 2B20, …articles
Development of a Novel Proteomic Approach for Mitochondrial Proteomics from Cardiac Tissue from Patients with Atrial FibrillationArticlesMaryam Goudarzi, Mark M. Ross, Weidong Zhou, Amy Van Meter, Jianghong Deng, Lisa M. Martin, …articles
Pressure Cycling Technology (PCT) Applications for DNA Extractions from Challenging Forensic SamplesForensicsSuzanne Gonzalez; Elizabeth Feller; Dixie Peters; Bruce Budowle; and Arthur Eisenberg University of North Texas …forensics
The Application of Alkaline Lysis and Pressure Cycling Technology in the Differential Extraction of DNA from Sperm and Epithelial Cells Recovered from Cotton SwabsPeer ReviewedDeepthi V. Nori1 & Bruce R. McCord1 1Department of Chemistry CP304, Florida International University, 11200 …peer-reviewed
Poster: Improved Tools for Examining Low Copy Number (LCN) DNA Obtained from Challenged or Degraded SamplesArticlesPamela Marshall, Jonathan King, Sarah Schmedes, Meredith Turnbough, Arthur Eisenberg and Bruce Budowle Department of …articles
Does LC Separation of Intact Proteins Hinder Identification of Bacterial Markers?Archived Publications and PostersMelinda A. McFarland ; Denis Andrzejewski; John H. Callahan; Steven M. Musser FDA-CFSAN, College Park, …archived-publications-and-posters
DNA Recovery by Pressure Cycling and its Potential Application to Differential ExtractionArchived Publications and PostersDeepthi Nori and Bruce R. McCord* Department of Chemistry and Biochemistry Florida International University mccordb@fiu.eduarchived-publications-and-posters
High-Resolution Respirometry for Mitochondrial Characterization of Ex Vivo Mouse TissuesArticlesCarles Cant´o1 and Pablo M. Garcia-Roves2 1Nestl´e Institute of Health Sciences S.A., Lausanne, Switzerland 2Diabetes …articles
Platform for Identification of Salmonella Serovar Differentiating Bacterial Proteins by Top-Down Mass Spectrometry: S. Typhimurium vs S. HeidelbergPeer ReviewedMelinda A. McFarland;* Denis Andrzejewski; Steven M. Musser; and John H. Callahan Spectroscopy and Mass …peer-reviewed
Selective Reduction of Ketones Using Water as a Hydrogen Source Under High Hydrostatic PressureArchived Publications and PostersAnna Tomin,a Alexander Lazarev,b Matthew P. Bere,a Hana Redjeba and B�la T�r�k*a Org. Biomol. Chem., …archived-publications-and-posters
Differences in Mitochondrial Function in Homogenated Samples from Healthy and Epileptic Specific Brain Tissues Revealed by High-Resolution RespirometryArchived Publications and PostersJohannes Burtscher a, Luca Zangrandi a, Christoph Schwarzer a, Erich Gnaiger b,c, a Dept. Pharmacology, …archived-publications-and-posters
The Effect of Pressure Cycling on Proteolytic Cleavage Efficiency, Reaction Time and Protein Sequence CoverageArchived Publications and PostersRoger Biringer1, Eric Bonneil2, Julian Saba1, Andreas Huhmer1, Pierre Thibault2archived-publications-and-posters
PCT-Related Poster Abstracts from ASMS 2014Archived Publications and PostersNew Products from Pressure BioSciences for Enhanced Proteomic Research Pressure BioSciences, Inc. 14 Norfolk Ave., …archived-publications-and-posters
Novel Efficient Alternatives for Essential Sample Preparation Techniques in Functional ProteomicsArchived Publications and PostersEmily Freeman and Alexander R. Ivanov Harvard School of Public Health, Department of Genetics and …archived-publications-and-posters
Screening for Drug-Drug Interactions Using a Targeted Proteomics StrategyArchived Publications and PostersDaniel B. Kassel1; Kheng B. Lim1; Melinda Manuel1; Teruaki Okuda2; Naomi Kamiguchi2; Christie L Hunter3; …archived-publications-and-posters
Fecal Lipidomics Profiling and Structural Identification using High Resolution LC-MS and HCD FragmentationArticlesSusan S. Bird1, 2; Katherine E. Gregory1, 3; Vera S. Gross4; Vasant R. Marur1; Alexander …articles
Application of High Pressure and Highly Stable Trypsin Aggregate Coating on Superparamagnetic Magnetite/Silica Nanoparticles for High Performance ProteomicsArticlesDaniel L�pez-Ferrer1, Byoungsoo Lee2, Jungbae Kim2 and Richard D. Smith1 1Pacific Northwest National Laboratory, Richland, …articles
Composition of Microbial Communities in Petroleum DepositsArticlesJamie Scott, Debarati Paul, Magan Green, Lewis R. Brown, and Mark L. Lawrence. College of …articles
Geographic Distribution of Rhizoctonia and Pythium Species in Soils from Dryland Cereal Cropping Systems in Eastern WashingtonArchived Publications and PostersK. L. SCHROEDER, P. A. Okubara, and T. C. Paulitz USDA-ARS, Washington State University, Pullman, …archived-publications-and-posters
A Comparison of Methods for Efficient Digestion of Protein TherapeuticsArchived Publications and PostersLorna L. Maheu, Heather M. Connelly, Adam G. Harder, and Steven L. Cockrill Analytical Sciences, …archived-publications-and-posters
The Proteomic Dataset for Bone Marrow Derived Human Mesenchymal Stromal Cells: Effect of in Vitro PassagingPeer ReviewedSamuel T. Mindayea; Jessica LoSurdob; Steven R. Bauerb; Michail A. Altermana aTumor Vaccines and Biotechnology …peer-reviewed
Pressure Enhanced Processes (PrEP) Enabling High Quality Two-Dimensional Gel Electrophoresis of Frankia mycelia and Vesicle StructuresArchived Publications and PostersLouis S. Tisa, Gary B. Smejkal Tom Berkelma, Chiara Rivas-Morello, Alexander Trachtenberg and Winston P. …archived-publications-and-posters
A Comparative Study of In-Gel Digestions Using Microwave and Pressure-Accelerated TechnologiesArchived Publications and PostersRudy Alvarado, Diana Tran, Bonnie Ching, and Brett S. Phinney* UC Davis Proteomics Core Facility, …archived-publications-and-posters
Seminar: Application of Pressure Cycling Technology (PCT) in Differential ExtractionArchived Publications and PostersDeepthi Nori*, MFS; Dr. Bruce R. McCord, PhD International Forensic Research Institute, Department of Chemistry …archived-publications-and-posters
Poster: Application of Pressure Cycling Technology (PCT) in Differential ExtractionArticlesDeepthi Nori*, MFS; Dr. Bruce R. McCord, PhD International Forensic Research Institute, Department of Chemistry …articles
Differential Extraction of Mixtures in Sexual Assault Casework Using Pressure Cycling Technology (PCT)ArticlesDeepthi Nori*, MFS; Dr. Bruce R. McCord, PhD International Forensic Research Institute, Department of Chemistry …articles
Identification and Validation of Vaccine Candidate Proteins by 2-Dimensional Mass Spectrometry Analysis of Group A StreptococcusArchived Publications and PostersLori C Stansberry; Angela Payne; Julie Skinner; Loren Schultz; Jon Heinrichs; Eberhard Durr Merck and …archived-publications-and-posters
Method for Recovery and Immunoaffinity Enrichment of Membrane Proteins Illustrated with Metastatic Ovarian Cancer TissuesPeer ReviewedLuke V. Schneider;1 Varsha Likhte;1 William H. Wright;1 Frances Chu;1 Emma Cambron;1 Anne Baldwin-Burnett;1 Jessica …peer-reviewed
Improved Extraction of DNA of Ca. Liberibacter Species from Plants and Cultivated Cells Using Pressure Cycling TechnologyArticlesA. Sechler1, A Marques2, N. Lawrence3, N. W. Schaad1 1FDWSRU, USDA-ARS, Fort Detrick, MD USA …articles
Proteomic Comparison of Sun-protected vs -Exposed and Young vs Gently-Aged Human EpitheliumArticles1 Facility Center California R.A. Eigenheer1, J.T. Smilowitz2 and B.S. Phinney1 1. Proteomics Core Facility, …articles
A Separation-Free Quantitative MS-Based Profiling Approach Using 2-AA Isotopically Labeled Substrates for High-Throughput Glycan ScreeningArchived Publications and PostersJustin M. Prien1, Lorna Maheu1, Brad Prater1, and Steve Cockrill1 1Analytical Science, Amgen, Longmont, Colorado …archived-publications-and-posters
Convenient and Reliable Extraction of Borrelia burgdorferi from Ticks Using Pressure Cycling Technology and the PCT ShredderRichard C. Tilton, Ph.D. Medical Diagnostics Laboratories
Pressure Cycling Technology (PCT) Augments Sensitivity of Detection and Robustness in Forensic DNA AnalysesBruce Budowle Department of Forensic and Investigative Genetics, Institute of Investigative Genetics, University of North …
A Need for Improved Sample Inactivation and Extraction Methods to Support Systems Biology Analysis of Biological Threat Organisms1 Bradford S. Powell and 2 Loreen L. Lofts 1 Bacteriology Division, 2 Virology Division …
Rapid Sample Preparation Methods for the Analysis of N-Linked GlycansArchived Publications and PostersZoltan Szabo, Andris Guttman, Tomas Rejtar and Barry L. Karger Barnett Institute, Boston, MA, USAarchived-publications-and-posters
Development of New Technology Approaches for High-Throughput Proteome AnalysisArchived Publications and PostersCapitalizing on thermodynamic principles to reduce sample preparation times from hours to minutes Daniel L�pez-Ferrer, …archived-publications-and-posters
High Pressure Direct Protein Extraction from Tissue – Trypsin Digest with Pressure Cycling Technology (PCT)Paul H. Pevsner, Jennifer Oprihory, Nicholas Sobol, Parth Kothiya, Zeineen A. Momin, Naresh Vasani, and …
(Fundamentals of) High-pressure Instruments for Innovation and DiscoveryEdmund Ting, Sc.D., Pressure BioSciences
Environmentally Benign Reduction of Organic Compounds in Water under High Hydrostatic PressureAnna Tomin, Alexander Lazarev, Bela Torok Pressure BioSciences, Inc. 14 Norfolk Ave., South Easton, MA …
Development of Essential Sample Preparation Techniques in Proteomics Using Ultra-High PressureEmily Freeman and Alexander R. Ivanov Harvard School of Public Health, HSPH Proteomics Resource, Department …
Comparison Between Ultra-High Pressure and Atmospheric Tryptic Digestion for Proteomic AnalysesArchived Publications and PostersE. Bonneil1, R. Biringer2, C. Bell1, P. Thibault1 1Institute for Research in Immunology and Cancer …archived-publications-and-posters
High Pressure Mediated Sample Preparation for Capillary Electrophoresis Analysis of N-Linked GlycansArchived Publications and PostersAndr�s Guttman1,2, Zolt�n Szab�1 and Barry L. Karger1 1 Barnett Institute, Northeastern University, Boston, MA …archived-publications-and-posters
High Pressure in Life Sciences – Trends and Future OpportunitiesAlexander Lazarev, PhD, Pressure BioSciences, Inc.
Trends and Applications of Hydrostatic Pressure in Biomedical Analysis: Exploring a Forgotten Thermodynamic DimensionArchived Publications and PostersAlexander Lazarev Pressure BioSciences, Inc. 14 Norfolk Ave., South Easton, MA 02375, USAarchived-publications-and-posters
Exploring Applications of High Pressure in Biological Sample PreparationAlexander Lazarev, Pressure BioSciences,Inc.
Forensic Testing Using Pressure Cycling Technology (PCT)Thomas E. Strader
Mechanistic Studies of the Pressure-Enhanced Tryptic DigestionAlexander Lazarev1; Vera Gross1; Greta Carlson1; Alexander Ivanov2 1Pressure BioSciences, Inc, South Easton, MA; 2Harvard …
Investigation of Pressure-Enhanced Trypsin ProteolysisVera Gross; Greta Carlson; Alexander R. Ivanov; Scott Walmsley; Alexey Nesvizhskii; and Alexander Lazarev Pressure …
Low Energy Mechanical Shredding: A New Approach for a Wide Range of Sample Preparation NeedsVera Gross1, Greta Carlson1, Gary Smejkal2. Heather Greenberg3, Bruce Kristal3, Luke Schneider4 and Alexander Lazarev1 …
Towards The Understanding of Hydrostatic Pressure Effects on Proteomic Sample Preparation MethodsAlexander Lazarev1; Vera Gross1; Greta Carlson1; Alexander R. Ivanov2 1Pressure BioSciences, Inc. 14 Norfolk Ave., …
Development and Applications of the Automated Benchtop Dynamic Pressure Generator for High Pressure Perturbation of Protein Structure and Protein Dynamics StudiesArchived Publications and PostersA. Lazarev, T. Straub, J. Behnke, E. Y. Ting Pressure BioSciences Inc., Boston, MA, USAarchived-publications-and-posters
The Future of H/D Exchange Analysis: A Proposed Integrated Workflow Pressure BioSciences, LEAP Technologies, Valco Instruments, and Sage-N ResearchPressure BioSciences, LEAP Technologies, Valco Instruments, and Sage-N Research
Pressure Cycling Technology (PCT): Potential Applications in Forensic Sample PreparationPressure BioSciences, Inc., 14 Norfolk Avenue, South Easton MA 02375
The PBI Shredder System: A Novel Approach for Affordable and Efficient Sample PreparationArchived Publications and Posters1Pressure BioSciences, Inc., South Easton, MA.; 2Harvard Catalyst Laboratory of Innovative Translational Technologies, Boston, MA.;3Brigham …archived-publications-and-posters
Direct Compressibility Measurements of Liquids up to 7 Kilobar Using Pressure Generator with Integrated Piston Position SensorArchived Publications and PostersAlexander Lazarev*, Vera Gross, Hembly Rivas, James Behnke, Edmund Y. Ting Pressure BioSciences, Inc. 14 …archived-publications-and-posters
Development of Automated Benchtop Dynamic Pressure Generator Platform for Biological Sample Preparation, High Pressure Perturbation of Protein Structure, and other Applications of Hydrostatic PressureAlexander Lazarev, Timothy Straub, James Behnke, Vera Gross, Greta Carlson and Edmund Y. Ting Pressure …
Development and Applications of the Automated Benchtop Dynamic Pressure Generator for High Pressure Bioscience ResearchAlexander Lazarev, Timothy Straub, James Behnke and Edmund Y. Ting Pressure BioSciences, Inc. 14 Norfolk …
Development of Compact Automated Benchtop Pressure Generator Platform Capable of Dynamic Pressure Control up to 7 KilobarArchived Publications and PostersAlexander Lazarev, Timothy Straub, James Behnke, Edmund Y. Ting Pressure BioSciences, Inc. 14 Norfolk Ave., …archived-publications-and-posters
Exploring Applications of High Pressure in Biological Sample PreparationAlexander Lazarev, Pressure BioSciences,Inc.
PCT-Related Poster Abstracts from ASMS 2014Archived Publications and PostersNew Products from Pressure BioSciences for Enhanced Proteomic Research Pressure BioSciences, Inc. 14 Norfolk Ave., …archived-publications-and-posters
New Products from Pressure BioSciences for Enhanced Proteomic Research Pressure BioSciences, Inc.14 Norfolk Ave., South Easton, MA 02375
Innovative Sample Preparation Tools for Proteomics and Analytical LaboratoriesPressure BioSciences, Inc. 14 Norfolk Ave., South Easton, MA 02375
Effective Semi-Automated Extraction of Intact Mitochondria from Solid Tissues Using Gentle Mechanical Homogenization and Pressure Cycling TechnologyArchived Publications and PostersVera S. Gross1, Greta Carlson1, Emily Freeman2, Alexander R. Ivanov2, Heather Greenberg3, Sergei Baranov3, Irina …archived-publications-and-posters
Improved Protein Extraction and Identification from Archival Formalin-fixed Paraffin-embedded Human Aortas using High Pressure and HeatZongming Fu and Jennifer Van Eyk Johns Hopkins University
Trypsin Coated Polymer Nanofibers and Its Application to Protein Digestion under the Pressure CycleDaeho Shin1, Han Sol Kim2, Jungbae Kim2 1BMTech Medial Co. Ltd., Seoul, Korea, 2Chemical and …
Population Proteomics: Embracing Genomic VariabilityRuedi Aebersold, ETH Zurich, Institute for Systems Biology, Zurich, Switzerland Abstract Only
Use of Laser Capture Microdissection with Pressure Cycle Sample Preparation to Analyze the Proteome of Retinal Sub-StructuresSascha Dammeier1, Eloed Koertvely2, Michelle Dierstein2, Franziska Klose3, Katja Schenke-Layland4, Marius Ueffing1 1Institute for Ophthalmic …
Demystifying Proteolytic Digestion Under High Pressure Cycling: Enzyme Specificity, Efficiency and Synergy of Pressure with Acid – Labile DetergentsArchived Publications and PostersVera Gross1; John Wilson2; Darryl Pappin2; Alexander Lazarev1 1Pressure BioSciences, Inc. Medford, MA; 2Protifi, LLC, …archived-publications-and-posters
The Signature Exosome Map for Bone Marrow Stromal Cells: Development of an Optimal Sample Preparation Approach Under High Pressure Cycling: Enzyme Specificity, Efficiency and Synergy of Pressure with Acid-Labile DetergentsArchived Publications and PostersQin (Stefanie) Liang1, Yamei Gao2, and Michail A. Alterman1   1Tumor Vaccines and Biotechnology Branch, …archived-publications-and-posters
PCT News September 2015
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High-Pressure EPR Reveals Conformational Equilibria and Volumetric Properties of Spin-Labeled ProteinsPeer ReviewedJohn McCoy and Wayne L. Hubbell PNAS January 25, 2011 108 (4) 1331-1336; https://doi.org/10.1073/pnas.1017877108peer-reviewed
High-Pressure Conformational Ensemble of Apomyoglobin Revealed by Double Electron-Electron ResonanceArchived Publications and PostersMichael Lerch; Zhongyu Yang; Evan Brooks; and Wayne L. Hubbell Poster | Jules Stein Eye …archived-publications-and-posters
Investigation of Pressure-Enhanced Trypsin ProteolysisVera Gross; Greta Carlson; Alexander R. Ivanov; Scott Walmsley; Alexey Nesvizhskii; and Alexander Lazarev
The Evaluation of Pressure-Assisted Enzymatic Digestion for the Optimal Digestion of Monoclonal AntibodiesArchived Publications and PostersYazen Jmeian; Eric Beil; Dariusz Janecki; Steven Pomerantz; Jennifer Nemeth Janssen Research & Development, Radnor, …archived-publications-and-posters
Improving the Efficiency and Throughput of an Enzymatic Digestion of Klotho using Pressure Cycling Technology (PCT)Archived Publications and PostersTaha Rezai1, Vera Gross2, Alexander Lazarev2, Mary Lopez1 1Thermo Fisher Scientific, Cambridge, MA; 2Pressure BioSciences …archived-publications-and-posters
Mechanistic Investigations of Hydrostatic Pressure Effects on Tryptic DigestionArchived Publications and PostersAlexander Lazarev1; Vera Gross1; Greta Carlson1; Alexander Ivanov2; Scott Walmsley3; Alexey Nesvizhskii3 1 Pressure Bioscience …archived-publications-and-posters
MALDI and LCMS Identifications of Early Protein and LA-ICP-MS Identification of Early Metal Biomarkers of Ionizing RadiationArchived Publications and PostersP. Pevsner1, G. Li2, N. Sobol1, D.C Miller1, D. Robertson2,3 1Department of Pathology and Anatomical …archived-publications-and-posters
Comparative Proteomics of Swine Tissue 2DLC/MS of Tissue Digestion Preliminary Protein AnalysisMatthew Lawrence Human Proteomics Program University of Wisconsin-Madison
Proteolysis-PrEP (Lysozyme): Effect of Pressure Cycling on Lysozyme ActivityIntroductionPressure cycling technology (PCT) has been proven to accelerate enzymatic protein digestion. For example, the …
Global Deglycosylation in High Throughput LC-MS Glycomics: Comparing Microwave, Pressure, and Ultrasound Effects on PNGase F with Human SerumArchived Publications and PostersScott R. Kronewitter, Gordon W. Slysz, Daniel Lopez-Ferrer, Matthew E. Monroe, Rui Zhao, Thomas L. …archived-publications-and-posters
Analysis of Tissue Biopsies by PCT-SWATHPCT-HD (PCT-SWATH)Tiannan Guo, MD, PhD, Aebersold Lab, IMSB, ETH Zurich Presented at International HUPO 2013 Subset …pct-hd-pct-swath
More Efficient Tissue Lysis and Protein Digestion with Lower Concentration of Denaturant Using Pressure Cycling TechnologyWen Yan1,2; Shiying Shao1,2; Vera Gross3; Alexander Lazarev3; Tiannan Guo1; Ruedi Aebersold1,4 1Institute of Molecular …
PCT-SWATH: pressure cycling technology coupled with SWATH mass spectrometry for fast, deep and reproducible proteomic analysisTiannan Guo1; Petri Kouvonen1; Chiek Koh Ching1; Ludovic Gillet1; Witold Wolski1; Hannes Rost1; George Rosenberger1; …
Mass Spectrometry-Based Proteomic Quest for Diabetes BiomarkersPeer ReviewedShiying Shaoa,b; Tiannan Guob; Ruedi Aebersoldb,c aDivision of Endocrinology, Tongji Hospital, Huazhong University of Science …peer-reviewed
Proteomic Investigation of Intra-Tumor HeterogeneityPCT-HD (PCT-SWATH)Tiannan Guo, MD, PhD Ruedi Aebersold Lab, Institute of Molecular Systems Biology, ETH Zurichpct-hd-pct-swath
New Australian Cancer Research Facility to Profile 70K Tumor Proteomes Over Next Seven Years – GenomeWebPCT-HD (PCT-SWATH)Adam Bonislawskipct-hd-pct-swath
Hands Free Sample Homogenization and Protein Extraction from Small Tissue Biopsy Using Pressure Cycling Technology and MicroPestlePCT-HD (PCT-SWATH)Shiying Shao1,2; Vera Gross3; Wen Yan1,2; Tiannan Guo2; Alexander Lazarev3; Ruedi Aebersold1,4 1Institute of Molecular …pct-hd-pct-swath
Application Note-PCT-HD: Homogenization, Extraction and Digestion of Small Tissue Samples for Proteomic ApplicationsThe PCT-HD system is a combination of two of PBI’s innovative sample preparation tools; the …
Quantifying Cancer Related Proteins via Targeting MS Assay ResourcesPCT-HD (PCT-SWATH)Ruedi Aebersold, Ph.D Institute of Molecular Systems Biology, ETH-Zurichpct-hd-pct-swath
Stratification of Histologically Indistinguishable Prostate Cancer Tissue Biopsy Samples Using Quantitative Proteotypes Obtained by PCT-SWATHPCT-HD (PCT-SWATH)Tiannan Guo1; Li Li2; Ulrich Wagner3; Qing Zhong3; et al. 1Dep Biol, Inst Mol Sys Biol, …pct-hd-pct-swath
Isolation of Functional Mitochondria from Whole Rat Brain Using a PBI Shredder and Pressure Cycling Technology (PCT)IntroductionIsolation of intact mitochondria from human and animal tissue is crucial for studies that focus …
Isolation of Mitochondria from Rat Lung Using The PCT Shredder and Pressure Cycling Technology (PCT)IntroductionIsolation of intact mitochondria from human and animal tissue is crucial for studies in aging, …
Isolation of Functional Mitochondria from Rat Skeletal Muscle Using The PCT Shredder with an Optional Pressure Cycling Technology (PCT) Processing StepIntroductionIsolation of intact mitochondria from human and animal tissue is crucial for studies in aging, …
Improved Protocols for Isolation of Intact Mitochondria from Tissue SamplesMitochondriaVera Gross1; Irina Stavrovskaya2; Sergei Baranov2; Greta Carlson1; Emily Freeman3; Alexander Ivanov3; Bruce Kristal2; Alexander …mitochondria
Intact and Functional Mitochondria from Solid Tissue: Effective Semi-Automated Extraction Using Gentle Mechanical Homogenization and Pressure Cycling TechnologyMitochondriaAlexander Lazarev1; Vera S. Gross1; Greta Carlson1; Emily Freeman2; Alexander R. Ivanov2; Heather Greenberg3; Sergei …mitochondria
Tissue Homogenates for Diagnosis of Mitochondrial Respiratory Function: Mouse Heart, Brain and LiverMitochondriaAndrea Eigentler;1 Mona Fontana-Ayoub;2 Erich Gnaiger1,2 1Medical University of Innsbruck, Department of Visceral, Transplant and Thoracic …mitochondria
Mitochondrial Respiration in Permeabilized Fibres versus Homogenate from Trout Heart and LiverMitochondriaCarolina Doerrier Velasco;1* Anna Draxl;1 Anita Wiethüchter;2 Andrea Eigentler;2 Erich Gnaiger1,2 1OROBOROS INSTRUMENTS Corp, High-Resolution Respirometry, Schöpfstr 18, …mitochondria
PBI-Shredder HRR- Set: Preparation of Tissue Homogenates for Diagnosis of Mitochondrial Respiratory FunctionMitochondriaAnna Draxl1; Andrea Eigentler2; Erich Gnaiger1,2 1OROBOROS INSTRUMENTS Corp, Schöpfstr 18, A-6020 Innsbruck, Austria, Email: erich.gnaiger@oroboros.at, www.oroboros.at, 2Medical University …mitochondria
The Best Approach: Homogenization or Manual Permeabilization of Human Skeletal Muscle Fibers for Respirometry?MitochondriaSteen Larsena; Regitze Kraunsoea; Martin Grama; Erich Gnaigerb; Jorn W. Helgea; Flemming Delaa aXlab, Center …mitochondria
High-Resolution Respirometry for Mitochondrial Characterization of Ex Vivo Mouse TissuesMitochondriaCarles Canto’1 and Pablo M. Garcia-Roves2 1Nestle’ Institute of Health Sciences S.A., Lausanne, Switzerland, 2Diabetes and …mitochondria
Differences in Mitochondrial Function in Homogenated Samples from Healthy and Epileptic Specific Brain Tissues Revealed by High-Resolution RespirometryMitochondriaJohannes Burtschera; Luca Zangrandia; Christoph Schwarzera; Erich Gnaigerb,c aDept. Pharmacology, Medical University Innsbruck, Peter-Mayr-Str. 1a, …mitochondria
Isolation of Mitochondria from Cell Cultures by PCT for Proteomic AnalysisArchived Publications and PostersVera Gross; Alexander V. Lazarev; Nathan P. Lawrence; and Richard T. Schumacher Pressure BioSciences, Inc., …archived-publications-and-posters
Discovery of Mitochondrial Protein Biomarkers of Atrial Fibrillation Using Unique Human Tissue SamplesMitochondriaMaryam Goudarzi1; Mark M. Ross1; Weidong Zhou1; Amy Van Meter1; Emanuel Petricoin1; Lance Liotta1; Lisa …mitochondria
Effective Semi-Automated Extraction of Intact Mitochondria from Solid Tissues Using Gentle Mechanical Homogenization and Pressure Cycling TechnologyMitochondriaVera S. Gross1; Greta Carlson1; Emily Freeman2; Alexander R. Ivanov2; Heather Greenberg3; et al. 1Pressure …mitochondria
Selective Reduction of Ketones Using Water as a Hydrogen Source under high Hydrostatic PressurePeer ReviewedAnna Tomina; Alexander Lazarevb; Matthew P. Berea; Hana Redjeba; and Bela Toroka,* Org. Biomol. Chem., …peer-reviewed
Development of Compact Automated Benchtop Pressure Generator Platform Capable of Dynamic Pressure Control up to 7 kilobarArchived Publications and PostersAlexander Lazarev; Timothy Straub; James Behnke; Edmund Y. Ting Pressure BioSciecnces | EHPG 2013 Posterarchived-publications-and-posters
Structure-Relaxation Mechanism for the Response of T4 Lysozyme Cavity Mutants to Hydrostatic PressurePeer ReviewedMichael T. Lercha,b; Carlos J. Lopeza,b; Zhongyu Yangab; Margaux J. Kreitmana,b; Joseph Horwitza; and Wayne …peer-reviewed
Mapping Protein Conformational Heterogeneity Under Pressure with Site-Directed Spin Labeling and Double Electron–Electron ResonancePeer ReviewedMichael T. Lercha,b; Zhongyu Yangka; Evan K. Brooksa; and Wayne L. Hubbella,b PNAS | Published …peer-reviewed
Fast and Efficient Protein Extraction in MicroTubes Using PCT μPestlesProteomics Application NotesIntroductionHomogenization and extraction from small tissue samples (<5.0 mg) requires scaled-down protocols that minimize sample …proteomics-application-notes
Improved Protein Recovery from Rat Pancreas Tissue Using Pressure Cycling Technology (PCT) and the ProteoSolve-SB Kit – 03/29/10Proteomics Application NotesIntroductionPancreatic cancer has a very high mortality rate, primarily due to the fact that it …proteomics-application-notes
Extraction of Proteins from 30 Million Year Old Amber Using The PCT Shredder and Pressure Cycling Technology (PCT)-020710Proteomics Application NotesIntroductionThe mass extinction of the dinosaurs, marked by the Cretaceous-Tertiary boundary, pales in magnitude compared …proteomics-application-notes
Electrophoretic Analyses of Proteins and Peptides Isolated From Cortical Bone Using Pressure Cycling Technology (PCT) – 04/17/07Proteomics Application NotesExtraction of proteins from extensively calcified osseous tissue, such as cortical bone has been particularly …proteomics-application-notes
The Proteome of Rhodopseudomonas palustris Revealed by Pressure Cycling Technology (PCT) and Two-Dimensional Gel Electrophoresis – 03/02/06Proteomics Application NotesRhodopseudomonas palustris is a Gram negative, purple, non-sulfur, phototropic bacterium, and is a metabolically versatile …proteomics-application-notes
Extraction of Proteins and RNA from Small Solid Tissue Samples Using PCT and FT 500-ND PULSE Tubes-080610Proteomics Application NotesIntroductionEfficient, reproducible and rapid tissue disruption and extraction of biomolecules are prerequisite for many biological …proteomics-application-notes
Total Protein Extraction from Small Tissue Samples Using PCT MicroTubes and the ProteoSolve-SB Kit -051610 – 05/16/10Proteomics Application NotesExtraction of total proteins from tissue has generally been limited by the poor solubility of …proteomics-application-notes
Pressure Cycling Technology (PCT) Reduces Effects of Inhibitors of the PCR – ManuscriptPeer ReviewedPamela L. Marshall; Jonathan L. King; Nathan P. Lawrence; Alexander Lazarev; Vera S. Gross; Bruce …peer-reviewed
Pressure Cycling Technology (PCT) Reduces Effects of Inhibitors of the PCRForensicsPam Marshall, PhD Candidate Mid America Forensic DNA Conference, April, 2013forensics
Proteolysis-PrEP: Optimization of Pressure Cycling Conditions for Protein Digestion with Trypsin in SolutionIntroductionPressure Cycling Technology (PCT) has been proven to accelerate enzymatic protein digestion. The positive effect …
Trypsin-Digestion.Final.pdf
Pressure-Accelerated Protein Digestion with Endoproteinase Lys-CIntroductionPressure Cycling Technology (PCT) has been proven to accelerate enzymatic protein digestion. The positive effect …
Glu-C-application-v2.pdfPressure BioSciences
Shredder Data BrochureShredder Applicationsshredder-applications
Value Proposition: PBI SHREDDER SYSTEMSShredder Applicationsshredder-applications
Isolation of Functional Mitochondria from Whole Rat Heart Using a PBI Shredder and Pressure Cycling Technology (PCT)
Isolation of Functional Mitochondria from Whole Rat Brain Using a PBI Shredder and Pressure Cycling Technology (PCT)Mitochondriamitochondria
Extraction of DNA from Cheese – 02/17/09DNA, etc.), Extractions (Protein, RNAdna etc extractions-protein rna
Detection of Propionibacterium acnes 16S rRNA and Lipase Genes from Sebum Samples Collected on Lipid-specific Adhesive Skin Strips and Processed by Pressure Cycling Technology (PCT) – 10/04/09Archived Publications and Postersarchived-publications-and-posters
Gene Expression Analysis by Microarray Using RNA Extracted by Pressure Cycling Technology (PCT) – 04/30/07Archived Publications and Postersarchived-publications-and-posters