Protein Refolding and Disaggregation

Protein Refolding and Disaggregation

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Confronting high-throughput protein refolding using high pressure and solution screens

M. Walid Qoronfleha,*, Lyndal K. Hesterbergb, Matthew B. Seefeldtb

aUniversity of Michigan and Core Technology Alliance-CTA, 1024 Wolverine Tower, 3003 State Street, Ann Arbor, MI 48109-1274, USA

bBaroFold Inc., 1825 33rd Street, Boulder, CO 80301, USA

High hydrostatic pressure as a tool to study protein aggregation and amyloidosis.

Randolph TW, Seefeldt M, Carpenter JF.

Department of Chemical Engineering, University of Colorado, Boulder, CO 80309, USA.

High-pressure refolding of bikunin: efficacy and thermodynamics.

Seefeldt MB1, Ouyang J, Froland WA, Carpenter JF, Randolph TW.

Department of Chemical and Biological Engineering, Center for Pharmaceutical Biotechnology, ECCH 111, University of Colorado, Boulder, CO 80309-0424, USA.

High-pressure studies of aggregation of recombinant human interleukin-1 receptor antagonist: thermodynamics, kinetics, and application to accelerated formulation studies.

Seefeldt MB1, Kim YS, Tolley KP, Seely J, Carpenter JF, Randolph TW

Department of Chemical and Biological Engineering, Center for Pharmaceutical Biotechnology, ECCH 111, University of Colorado, Boulder, CO 80309-0242, USA.

Specific volume and adiabatic compressibility measurements of native and aggregated recombinant human interleukin-1 receptor antagonist: density differences enable pressure-modulated refolding.

Seefeldt MB1, Crouch C, Kendrick B, Randolph TW.

Department of Chemical and Biological Engineering, University of Colorado, Boulder, Colorado 80309, USA.