Proteomic Dynamics of Colorectal Cancer Evolution Identifies Microenvironment Modulator PLOD2 as a Potential Novel Drug Target
• Proteomic dynamics of colorectal cancer evolution using PCTDIA.
• >6500 proteins quantified in 180 samples with high reproducibility (R2=0.931)
• 185 proteins involved in microenvironmental regulation contribute to colorectal cancer evolution.
• PLOD2 as a potential novel drug target for colorectal cancer patients with high expression of PLOD2.